22265-77-6

Usage

Uses

Used in Chemical Manufacturing:
1-(2-Ethylphenyl)-2-thiourea is used as a chemical intermediate for the synthesis of other chemicals. Its role in this application is to facilitate the production of various compounds through chemical reactions.
Used in Chemical Reactions:
1-(2-Ethylphenyl)-2-thiourea is used as a reactant in various chemical reactions, contributing to the formation of new compounds. Its presence in these reactions is essential for achieving the desired outcomes.

InChI:InChI=1/C9H12N2S/c1-2-7-5-3-4-6-8(7)11-9(10)12/h3-6H,2H2,1H3,(H3,10,11,12)

Upstream product

• 578-54-1 ortho-ethylaniline 
• 532-55-8 Benzoyl isothiocyanate 
• 88884-36-0 1-benzoyl-3-(2-ethylphenyl)-2-thiourea 
• 1147550-11-5 ammonium thiocyanate 

Downstream Products

• 75276-66-3 1-(o-ethylphenyl)-4,6-dimethylpyrimidin-2(1H)-thione 
• 75276-66-3 1-(2-Ethyl-phenyl)-4,6-dimethyl-1H-pyrimidine-2-thione 
• 89069-98-7 1-(2-Ethyl-phenyl)-2-methyl-isothiourea 
• 412919-79-0 N-(2-ethylphenyl)-2',4'-dimethyl-4,5'-bi-1,3-thiazol-2-amine 
• 88884-62-2 N-(2-Ethyl-phenyl)-morpholine-4-carboxamidine; hydriodide 
• 139331-50-3 5-Ethyl-2-{3-[4-(4-fluoro-phenyl)-piperazin-1-yl]-propyl}-4H-benzo[1,4]thiazin-3-one 
• 139331-76-3 2-Amino-3-ethyl-benzenethiol 
• 139331-68-3 4-ethyl-1,3-benzothiazol-2-amine 

Relevant academic research and scientific papers

The in vivo antinociceptive and μ-opioid receptor activating effects of the combination of N-phenyl-2′,4′-dimethyl-4,5′-bi-1,3-thiazol-2-amines and naloxone

Morphine is widely used for the treatment of severe pain. This analgesic effect is mediated principally by the activation of μ-opioid receptors (MOR). However, prolonged activation of MOR also results in tolerance, dependence, addiction, constipation, nau

OPIOID RECEPTOR MODULATORS AND USE THEREOF

Disclosed is an in vitro screening method for identifying an antagonist-to-agonist allosteric modifier of a mu-opioid receptor and an in vivo method for confirming that a test compound is such a modifier of a mu-opioid receptor. Also disclosed is a method

Structural requirement(s) of N-phenylthioureas and benzaldehyde thiosemicarbazones as inhibitors of melanogenesis in melanoma B 16 cells

In order to define the structural requirements of phenylthiourea (PTU), a series of thiourea and thiosemicarbazone analogs were prepared and evaluated as inhibitors of melanogenesis in melanoma B16 cells. The most potent analog was 2-(4-tert-butylbenzylidene)hydrazinecarbothioamide (1u) with an IC50 value of 2.7 μM in inhibition of melanogenesis. The structure for potent inhibitory activity of these derivatives are required with the direct connection of π-planar structure to thiourea without steric hinderance in PTU derivatives and the hydrophobic substituent at para position in case of semicarbazones.

Novel synthetic approach to N-aryl-4-(3-pyridyl)thiazol-2-amine and analogues using HMCM-41 as catalyst, and their biological evaluation as human platelet aggregation inhibitors

A novel synthetic approach to N-aryl-4-(3-pyridyl)thiazol-2-amine and analogues using HMCM-41, a mesoporous aluminosilicate catalyst and their in vitro ADP-induced platelet aggregation inhibitory activity on human blood platelets is described. Among the test compounds N-(2′-flourophenyl)-4-(3-pyridyl)thiazol-2-amine (9e) was found to be the most potent, IC50 = 4.84 × 10-7 M.

Synthesis and biological activities of new 1,4-benzothiazine derivatives

New 2H-1,4-benzothiazin-3(4H)-one derivatives possessing (4-phenyl-1-piperazinyl)alkyl moieties at the 2-position were synthesized and tested for calcium antagonistic and calmodulin antagonistic activities. Antihypertensive effects in spontaneously hypertensive rats were also evaluated. In general, these compounds were rather weak calcium channel blockers, although, in contrast, many of them had moderate to potent calmodulin antagonistic activity, and 2-[3-(4-(4-fluorophenyl)-1-piperazinyl]propyl]-2H-1,4-benzothiazin-3(4H )-one derivatives 45, 74 and 75 showed potent antihypertensive effects.

Improved Procedures for the Preparation of Cycloalkyl-, Arylalkyl-, and Arylthioureas

An improved procedure for the preparation of arylthioureas consists of the reaction of benzoyl isothiocyanate with anilines in acetone and debenzoylation of the resultant N-aryl-N'-benzoylthioureas with 5percent aqueous sodium hydroxide.Bicycloalkylthioureas and N-(arylalkyl)thioureas (e.g. 9H-9-fluorenylthiourea) are directly prepared from the corresponding isothiocyanates and ammonia.

Heterocyclic derivatives of guanidine

5-Membered, 6-membered and 7-membered heterocyclic derivatives of guanidine having hypoglycemic activity.