2227-73-8Relevant academic research and scientific papers
Cascade reactions to 2,4-disubstituted thiazoles via ligand-free palladium(II)-catalyzed C(sp)–C(sp2) coupling
Wang, Zi-Juan,Chen, Wen-Teng,He, Chang,Luo, Hao-Fan,Zhang, Guo-Lin,Yu, Yong-Ping
, (2020/01/28)
A simple construction for various 2,4-disubstituted thiazoles via palladium(II)-catalyzed C(sp)–C(sp2) and C-N cascade coupling reactions was developed. Various substrates can be tolerated with good yields. And its ligand-free condition demonst
Aryliodoazide synthons: A different approach for diversified synthesis of 2-aminothiazole, 1,3-thiazole, and 1,3-selenazole scaffolds
Majnooni, Sahar,Duffield, Joseph,Price, Jessica,Khosropour, Ahmad Reza,Zali-Boeini, Hassan,Beyzavi, M. Hassan
supporting information, p. 516 - 521 (2019/08/01)
Several straightforward and practical processes have been established for the construction of 2-aminothiazoles, 1,3-thiazoles and 1,3-selenazoles from aryliodoazides. These strategies successfully proceed with a wide spectrum of substituted thioamides and its derivatives producing the resulting five-membered heterocycles obtained in satisfactory yields. The unique features of these protocols are operational simplicity and highly functional group tolerance, which make them convenient and practical routes for the preparation of various libraries of 2-aminothiazoles, 1,3-thiazoles, and 1,3-selenazoles.
