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222713-10-2

2,6-Piperidinedione, 3-(1,3-dihydro-1-oxo-2H-isoindol-2-yl)-1-[(4-methoxyphenyl)methyl]- is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 222713-10-2 Structure

  • Basic information

    1. Product Name: 2,6-Piperidinedione, 3-(1,3-dihydro-1-oxo-2H-isoindol-2-yl)-1-[(4-methoxyphenyl)methyl]-
    2. Synonyms:
    3. CAS NO:222713-10-2
    4. Molecular Formula: C21H20N2O4
    5. Molecular Weight: 364.401
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 222713-10-2.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 2,6-Piperidinedione, 3-(1,3-dihydro-1-oxo-2H-isoindol-2-yl)-1-[(4-methoxyphenyl)methyl]-(CAS DataBase Reference)
    10. NIST Chemistry Reference: 2,6-Piperidinedione, 3-(1,3-dihydro-1-oxo-2H-isoindol-2-yl)-1-[(4-methoxyphenyl)methyl]-(222713-10-2)
    11. EPA Substance Registry System: 2,6-Piperidinedione, 3-(1,3-dihydro-1-oxo-2H-isoindol-2-yl)-1-[(4-methoxyphenyl)methyl]-(222713-10-2)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 222713-10-2(Hazardous Substances Data)

222713-10-2 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 222713-10-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,2,2,7,1 and 3 respectively; the second part has 2 digits, 1 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 222713-10:
(8*2)+(7*2)+(6*2)+(5*7)+(4*1)+(3*3)+(2*1)+(1*0)=92
92 % 10 = 2
So 222713-10-2 is a valid CAS Registry Number.

222713-10-2Relevant articles and documents

Thalidomide metabolites and analogues. 3. Synthesis and antiangiogenic activity of the teratogenic and TNFα-modulatory thalidomide analogue 2-(2,6-dioxopiperidine-3-yl)phthalimidine

Luzzio, Frederick A.,Mayorov, Alexander V.,Ng, Sylvia S. W.,Kruger, Erwin A.,Figg, William D.

, p. 3793 - 3799 (2007/10/03)

Versatile synthesis of the teratogenic, TNFα-modulatory, and antiangiogenic thalidomide analogue 2-(2,6-dioxopiperidine-3-yl)phthalimidine (1) and its direct antiangiogenic properties are described. With thalidomide or thalidomide derivatives as precursors, the synthesis involved either carbonyl reduction/thiation-desulfurization or carbonyl reduction/acyliminium ion reduction protocols. Compared to earlier studies with thalidomide, which was only active with microsomal treatment, 1 exhibited marginal inhibitory activity in the rat aortic ring assay, thereby demonstrating the requirement for metabolic activation.

A facile scheme for phthalimide ? phthalimidine conversion

Luzzio, Frederick A.,Piatt Zacherl, DeAnna,Figg, William D.

, p. 2087 - 2090 (2007/10/03)

Desulfurization of phenylthiolactams using an ultrasound-promoted Raney nickel protocol yields the corresponding N-substituted phthalimidines. Benzylic oxidation of the N-substituted phthalimidines by treatment with 2,2'-bipyridinium chlorochromate/m-chloroperbenzoic acid (BPCC/MCPBA) affords the original phthalimides. The reduction-desulfurization is applied to the preparation of a deoxythalidomide derivative which is a TNF-α inhibitor.

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