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22272-18-0

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22272-18-0 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 22272-18-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,2,2,7 and 2 respectively; the second part has 2 digits, 1 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 22272-18:
(7*2)+(6*2)+(5*2)+(4*7)+(3*2)+(2*1)+(1*8)=80
80 % 10 = 0
So 22272-18-0 is a valid CAS Registry Number.

22272-18-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-chloro-3-(octylamino)naphthalene-1,4-dione

1.2 Other means of identification

Product number -
Other names 2-chloro-3-octylamino-[1,4]naphthoquinone

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:22272-18-0 SDS

22272-18-0Downstream Products

22272-18-0Relevant articles and documents

Synthetic schistosomicides. XIV. 1,4-naphthoquinone mono(O-acyloximes), 4-amino-1,2-naphthoquinones, 2-amino-3-chloro-1,4-naphthoquinones, and other naphthoquinones.

Elslager,Werbel,Worth

, p. 104 - 109 (1970)

-

Antimalarial N1, N3-Dialkyldioxonaphthoimidazoliums: Synthesis, Biological Activity, and Structure-activity Relationships

Ahenkorah, Stephen,Birkholtz, Lyn-Marie,Coertzen, Dina,Fridianto, Kevin,Go, Mei-Lin,Haynes, Richard K.,Lam, Yulin,Tan, Kevin S. W.,Tong, Jie Xin,Wittlin, Sergio

supporting information, p. 49 - 55 (2020/02/06)

Here we report the nanomolar potencies of N1,N3-dialkyldioxonaphthoimidazoliums against asexual forms of sensitive and resistant Plasmodium falciparum. Activity was dependent on the presence of the fused quinone-imidazolium entity and lipophilicity imparted by the N1/N3 alkyl residues on the scaffold. Gametocytocidal activity was also detected, with most members active at IC50 1 μM. A representative analog with good solubility, limited PAMPA permeability, and microsomal stability demonstrated oral efficacy on a humanized mouse model of P. falciparum.

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