222732-65-2

Upstream product

• 164655-89-4 4-[17β-methoxy-17α-(methoxymethyl)-3-oxoestra-4,9-dien-11β-yl]benzaldehyde 

Downstream Products

• 163883-86-1 J₉₀₀ 
• 164656-17-1 11β-[4-(methoximinomethyl)phenyl]-17β-hydroxy-17α-methoxymethyl-estra-4,9-diene-3-on 

Relevant academic research and scientific papers

METHOD FOR PREPARING 4-[17β-METHOXY-17α-METHOXYMETHYL-3-OXOESTRA-4,9-DIEN-11β-YL]BENZALDEHYDE (E)-OXIME (ASOPRISNIL)

The present invention relates to a method for the reliable and reproducible preparation of 4-[17β-methoxy-17α-methoxymethyl-3-oxoestra-4,9-dien-llβ- yl]benzaldehyde (E)-oxime (asoprisnil) on the pilot and manufacturing scale. Asoprisnil, which is prepared by this method, is distinguished by a very good physical stability and is therefore particularly suitable for the manufacture of solid pharmaceutical forms (tablets, coated tablets, etc.).

11-BENZALDOXIME-ESTRA-DIENE DERIVATIVES, METHODS FOR THEIR PRODUCTION AND PHARMACEUTICALS CONTAINING THESE COMPOUNDS

This invention relates to new 11-benzaldoxime-estra-diene derivatives of the general formula I STR1 and their pharmaceutically acceptable salts, a method for their production, and pharmaceuticals containing such compounds.The compounds described sho