222734-75-0Relevant academic research and scientific papers
Asymmetric synthesis of a neuroprotective and orally active N-methyl-D-aspartate receptor ion-channel blocker, CNS 5788
Padmanabhan, Seetharamaiyer,Lavin, Ruth C.,Durant, Graham J.
, p. 3455 - 3457 (2000)
Asymmetric synthesis of N-(2-chloro-5-methylthiophenyl)-N'-(3-methylsulfinylphenyl)-N'-methylguanidine (CNS 5788) was achieved in high enantiomeric excess through condensation of the cyanamide derivative, 6 and the sulfinylaniline hydrochloride, 5. The key step involved the asymmetric oxidation of N-methyl-3-methylthioaniline using a Davis reagent. Copyright (C) 2000 Elsevier Science Ltd.
Pharmaceutically active compound and methods of use
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Page column 15, (2008/06/13)
This invention relates to racemic and optically active N-(2-chloro-5-methylthiophenyl)-N′-(3-methylsulfinylphenyl)-N′-methylguanidine, N-(2-chloro-5-methylsulfinylphenyl)-1-(7-trifluoromethyl- 1,2,3,4-tetrahydroquinolinyl)carboximidamide, and N-(3-methyls
