22278-80-4

Upstream product

• 881-90-3 4-benzylidene-2-methyl-2-oxazolin-5-one 
• 2231-57-4 Thiocarbohydrazide 
• 55065-02-6 2-(N-acetylamino)cinnamic acid 
• 38879-46-8 (Z)-4-benzylidene-2-methyl-5(4H)-oxazolone 
• 156-06-9 2-oxo-3-(phenyl)propionic acid 

Downstream Products

• 202650-92-8 6-Benzyl-3-mercapto-4-{[1-p-tolyl-meth-(E)-ylidene]-amino}-4H-[1,2,4]triazin-5-one 
• 202650-96-2 6-Benzyl-4-{[1-(4-chloro-phenyl)-meth-(E)-ylidene]-amino}-3-mercapto-4H-[1,2,4]triazin-5-one 
• 202650-93-9 6-Benzyl-3-mercapto-4-{[1-(4-methoxy-phenyl)-meth-(E)-ylidene]-amino}-4H-[1,2,4]triazin-5-one 
• 357915-21-0 3-benzyl-7-(p-chlorophenyl)-8H-[1,2,4]triazino[3,4-b][1,3,4]thiadiazin-4-one 
• 1105064-87-6 C₂₀H₁₆N₆O₄S 
• 1105064-92-3 C₂₁H₁₈N₆O₄S 
• 1105064-96-7 C₂₁H₁₈N₆O₅S 

Relevant academic research and scientific papers

Synthesis and Acaricidal Activity of Some New 1,2,4-Triazine Derivatives

A new series of 1,2,4-triazine derivatives were designed, synthesized, and identified on the basis of IR, 1H-NMR, 13C-NMR, and EI-MS spectral data. The potent acaricidal activity of 1,2,4-triazine derivatives against eggs and adult female of Tetranychus urticae (Koch) was assessed compared with pyridaben under laboratory conditions. Structure acaricidal activity relationships of the promising 1,2,4-triazine derivatives were analyzed for eggs and adult female; the nature and position of the substituents were important in demonstration of the activities.

An Easy Access to Construct Some Fused 1,2,4-Triazines with Ring Junction Nitrogen Systems and Their Biological Evaluation

The chemical reactivity of 4-amino-6-benzyl-3-mercapto-1,2,4-triazine-5(4H)-one (1) towards various aliphatic or/and mono and bis aromatic carboxylic acid derivatives to give the corresponding fused heterocyclic systems, 1,3,4-thiadiazoles 4, 5, 6, which incorporating 1,2,4-triazine nucleus was achieved. Moreover, compound 1 was subjected to react either with halo acetic acids or bromo ester to afford the respective fused nitrogen ring junction systems, thiadiazole 2 and 3, or thiadiazine 7. However, the tetracyclic ring system 9 was furnished through condensation reaction of isatine with triazine 1. In addition, some of the new synthesized compounds were evaluated as an antioxidant and antitumor agents.

An Easy Access to Construct Some New Fused 1,2,4-Triazines with Ring Junction Nitrogen Systems and Their Biological Evaluation

The chemical reactivity of 4-amino-6-benzyl-3-mercapto-1,2,4-triazine-5(4H)-one (1) towards various aliphatic or/and mono and bis aromatic carboxylic acid derivatives to give the corresponding fused heterocyclic systems, 1,3,4-thiadiazoles 4, 5, 6, which incorporating 1,2,4-triazine moiety was achieved. Moreover, compound 1 was subjected to reaction either with halo acetic acids or bromo ester to afford the respective fused nitrogen ring junction systems, thiadiazole 2 and 3 or thiadiazine 7. However, while the tetracyclic ring system 9 was furnished through condensation reaction of isatine with triazine 1. In addition, some of the new synthesized compounds were evaluated as an antioxidant and antitumor agents.

Synthesis and antimicrobial activities of a new series of 4-S-[41-amino-51-oxo-61-substituted benzyl-41,51-dihydro-11,21,41-triazin-3-yl]mercaptoacetyl-3-arylsydnones

The synthesis of some 4-S-(41-amino-51-oxo-61-substituted benzyl-41,51-dihydro-11,21,41-triazin-3-yl)mercaptoacetyl-3-arylsydnones by the reaction of 3-aryl-4-bromoacetylsydnones with 6-substituted-4-amino-3-mercapto-1,2,4-triazin-5-ones is described. The IR, 1H NMR, mass spectra and elemental analysis characterized the newly synthesized compounds. The synthesized compounds were screened for their antimicrobial activity. All the compounds showed higher activity than that of standard drug during antimicrobial studies and the activity was comparable with the standard drug for antifungal activity.

Studies on arylmethyltriazinone derivatives-Part II. Synthesis and antifungal properties of 2-aminomethyl-4-(arylidene)amino-6-arylmethyl-3-mercapto-1, 2,4-triazin-5(4H)-ones

The preparation of twenty new 2-aminomethyl-4-(arylidene)amino-6-arylmethyl-3-mercapto-1,2,4-triazin-5(4H)- ones(4) is described. The structural elucidation of all the compounds is carried out on the basis of analytical and spectral data. The newly synthesized compounds are evaluated for their antifungal activity against Candida albicans and Paecileomyces variotti.

Synthesis of biologically active 4-amino-6-arylmethyl-3-mercapto-1,2,4-triazin-5(4H)-ones and their Schiff bases

Three arylpyruvic acids 2 are condensed with thiocarbohydrazide (3) in aqueous ethanol to yield 4-amino-6-arylmethyl-3-mercapto-1,2,4-triazin-5(4H)-ones 4. In a modified method these title compounds 4 have also been prepared by direct condensation of the

Derivatives of 1,2,4-Triazin-5-one

3-Mercapto-1,2,4-triazin-5-ones were obtained by the reaction of thiosemicarbazide with α-keto carboxylic acids, 2-cyano-2-propanol, isatin, and 5-furfurylidenethiazolidine-2,4-dione.The first three methods gave high yields.

Herbicidal agents

3-[HYDROGEN-, (UNSUBSTITUTED AND HALO, AMINO, NITRO, ALKYL, ALKANOYL, ALKOXY, ALKYLMERCAPTO, ARYLOXY AND/OR ARYL-MERCAPTO-SUBSTITUTED) ALIPHATIC-, CYCLOALIPHATIC-, ARALIPHATIC-, ARYL-, OR HETEROCYCLIC- -SUBSTITUTED OXY, MERCAPTO OR AMINO]4-[AMINO; MONO AND DI (UNSUBSTITUTED AND CYANO, HYDROXY AND/OR HALO-SUBSTITUTED) ALKYL- AND/OR ALKANOYL-AMINO; N-heterocyclic; or N-(unsubstituted and aryl, haloaryl, alkoxyaryl, nitroaryl and/or heterocyclic- substituted) alkylidene or cycloalkylidene]-6-[(unsubstituted and halo, nitro, carbo lower alkoxy, alkyl, alkoxy, alkylmercapto, aralkylmercapto, aryloxy and/or arylmercapto-substituted) aliphatic, cycloaliphatic, araliphatic, aryl, or heterocyclic]-1,2,4-triazine-5-ones, which possess herbicidal properties, and which may be produced by conventional methods.