22278-80-4

Basic information

• Product Name: 1,2,4-Triazin-5(2H)-one, 4-amino-3,4-dihydro-6-(phenylmethyl)-3-thioxo-
• CAS NO: 22278-80-4
• Molecular Formula: C10H10N4OS
• Molecular Weight: 234.282
• Mol File: 22278-80-4.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: 1,2,4-Triazin-5(2H)-one, 4-amino-3,4-dihydro-6-(phenylmethyl)-3-thioxo-(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2,4-Triazin-5(2H)-one, 4-amino-3,4-dihydro-6-(phenylmethyl)-3-thioxo-(22278-80-4)
• EPA Substance Registry System: 1,2,4-Triazin-5(2H)-one, 4-amino-3,4-dihydro-6-(phenylmethyl)-3-thioxo-(22278-80-4)

Safety Data

• Hazardous Substances Data: 22278-80-4(Hazardous Substances Data)

Upstream product

• 156-06-9 2-oxo-3-(phenyl)propionic acid 
• 2231-57-4 Thiocarbohydrazide 
• 881-90-3 4-benzylidene-2-methyl-2-oxazolin-5-one 
• 55065-02-6 2-(N-acetylamino)cinnamic acid 
• 38879-46-8 (Z)-4-benzylidene-2-methyl-5(4H)-oxazolone 

Downstream Products

• 22285-41-2 4-amino-6-benzyl-3-methylthio-4,5-dihydro-1,2,4-triazin-5-one 
• 1105064-87-6 C₂₀H₁₆N₆O₄S 
• 1105064-92-3 C₂₁H₁₈N₆O₄S 
• 1105064-96-7 C₂₁H₁₈N₆O₅S 

Relevant articles and documents

Synthesis and Acaricidal Activity of Some New 1,2,4-Triazine Derivatives

A new series of 1,2,4-triazine derivatives were designed, synthesized, and identified on the basis of IR, 1H-NMR, 13C-NMR, and EI-MS spectral data. The potent acaricidal activity of 1,2,4-triazine derivatives against eggs and adult female of Tetranychus urticae (Koch) was assessed compared with pyridaben under laboratory conditions. Structure acaricidal activity relationships of the promising 1,2,4-triazine derivatives were analyzed for eggs and adult female; the nature and position of the substituents were important in demonstration of the activities.

An Easy Access to Construct Some New Fused 1,2,4-Triazines with Ring Junction Nitrogen Systems and Their Biological Evaluation

The chemical reactivity of 4-amino-6-benzyl-3-mercapto-1,2,4-triazine-5(4H)-one (1) towards various aliphatic or/and mono and bis aromatic carboxylic acid derivatives to give the corresponding fused heterocyclic systems, 1,3,4-thiadiazoles 4, 5, 6, which incorporating 1,2,4-triazine moiety was achieved. Moreover, compound 1 was subjected to reaction either with halo acetic acids or bromo ester to afford the respective fused nitrogen ring junction systems, thiadiazole 2 and 3 or thiadiazine 7. However, while the tetracyclic ring system 9 was furnished through condensation reaction of isatine with triazine 1. In addition, some of the new synthesized compounds were evaluated as an antioxidant and antitumor agents.

Studies on arylmethyltriazinone derivatives-Part II. Synthesis and antifungal properties of 2-aminomethyl-4-(arylidene)amino-6-arylmethyl-3-mercapto-1, 2,4-triazin-5(4H)-ones

The preparation of twenty new 2-aminomethyl-4-(arylidene)amino-6-arylmethyl-3-mercapto-1,2,4-triazin-5(4H)- ones(4) is described. The structural elucidation of all the compounds is carried out on the basis of analytical and spectral data. The newly synthesized compounds are evaluated for their antifungal activity against Candida albicans and Paecileomyces variotti.