2228-04-8 Usage
General Description
ETHYL (9H-PURIN-6-YL)ACETATE is a chemical compound with the molecular formula C10H11N5O2. It is a derivative of purine and is commonly used in the pharmaceutical industry as a building block for the synthesis of various compounds. It is also used in the production of flavor and fragrance compounds, and as an intermediate in organic synthesis. ETHYL (9H-PURIN-6-YL)ACETATE is a colorless liquid with a fruity odor, and it is flammable and volatile. It is important to handle this chemical with care and in accordance with safety guidelines.
Check Digit Verification of cas no
The CAS Registry Mumber 2228-04-8 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 2,2,2 and 8 respectively; the second part has 2 digits, 0 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 2228-04:
(6*2)+(5*2)+(4*2)+(3*8)+(2*0)+(1*4)=58
58 % 10 = 8
So 2228-04-8 is a valid CAS Registry Number.
InChI:InChI=1/C9H10N4O2/c1-2-15-7(14)3-6-8-9(12-4-10-6)13-5-11-8/h4-5,8H,2-3H2,1H3
2228-04-8Relevant articles and documents
Synthesis of (purin-6-yl)acetates and their transformations to 6-(2-hydroxyethyl)-and 6-(carbamoylmethyl)purines
Hasnik, Zbynek,Pohl, Radek,Klepetarova, Blanka,Hocek, Michal
experimental part, p. 1035 - 1059 (2010/04/24)
A novel approach to the synthesis of (purin-6-yl)acetates was developed based on Pdcatalyzed cross-coupling reactions of 6-chloropurines with a Reformatsky reagent. Their reduction with NaBH4 and treatment with MnO2 gave 6-(2-hydroxyethyl)purines, while reactions with amines in presence of NaCN afforded 6-(carbamoylmethyl)purines. Mesylation of the 6-(2-hydroxyethyl)purines followed by nucleophilic substitutions gave rise to several 6-(2-substituted ethyl)purines. This methodology was successfully applied to the synthesis of substituted purine bases and nucleosides for cytostatic and antiviral activity screening. None of the compounds exerted significant activity.
