22280-60-0

Basic information

• Product Name: 6-Chloro-2-methyl-3-nitropyridine
• Synonyms: TIMTEC-BB SBB003832;TIMTEC-BB SBB003830;6-CHLORO-3-NITRO-2-METHYLPYRIDINE;6-CHLORO-3-NITRO-2-PICOLINE;6-CHLORO-2-METHYL-3-NITROPYRIDINE;2-CHLORO-6-METHYL-5-NITROPYRIDINE;2-CHLORO-6-METHYL-3-NITROPYRIDINE;2-CHLORO-5-NITRO-6-METHYLPYRIDINE
• CAS NO: 22280-60-0
• Molecular Formula: C₆H₅ClN₂O₂
• Molecular Weight: 172.57
• Product Categories: compounds of pyridine;Pyridine;Pyridines;Boronic Acid;Chlorinated heterocyclic series;pyridine series;Heterocycle-Pyridine series
• Mol File: 22280-60-0.mol
• Article Data: 15

Chemical Properties

• Melting Point: 54-58 °C
• Boiling Point: 200°C (rough estimate)
• Flash Point: 108.5 °C
• Appearance: Light beige to brown/Powder
• Density: 1.5610 (rough estimate)
• Vapor Pressure: 0.00597mmHg at 25°C
• Refractive Index: 1.5500 (estimate)
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• PKA: -3.26±0.10(Predicted)
• CAS DataBase Reference: 6-Chloro-2-methyl-3-nitropyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 6-Chloro-2-methyl-3-nitropyridine(22280-60-0)
• EPA Substance Registry System: 6-Chloro-2-methyl-3-nitropyridine(22280-60-0)

Safety Data

• Hazard Codes: Xn,Xi
• Statements: 36/37/38-20/21/22-22
• Safety Statements: 36/37/39-26
• HazardClass: IRRITANT
• Hazardous Substances Data: 22280-60-0(Hazardous Substances Data)

Usage

Chemical Properties

Light yellow Cryst

Uses

6-Chloro-2-methyl-3-nitropyridine has been used as a reactant for the synthesis of fluorine-containing pyridinealdoxime derivatives as treatment of organophosphorus nerve-agent poisoning.

InChI:InChI=1/C6H5ClN2O2/c1-4-2-3-5(9(10)11)6(7)8-4/h2-3H,1H3

Upstream product

• 33986-37-7 6-methyl-2-nitraminopyridine 
• 1824-81-3 2-Amino-6-methylpyridine 
• 10026-13-8 phosphorus pentachloride 
• 28489-45-4 6-methyl-5-nitropyridin-2(1H)-one 
• 22280-62-2 6-methyl-5-nitro-2-pyridinamine 
• 109-06-8 α-picoline 
• 28489-45-4 6-methyl-5-nitropyridin-2-ol 

Downstream Products

• 28489-45-4 6-methyl-5-nitropyridin-2-ol 
• 5467-69-6 6-methoxy-3-nitro-2-picoline 
• 3430-10-2 2-methyl-3-pyridinamine 
• 164666-68-6 3-amino-6-chloro-2-methylpyridine 
• 18699-87-1 2-methyl-3-nitropyridine 
• 28489-37-4 (6-methyl-5-nitro-[2]pyridyl)-hydrazine 
• 77917-45-4 1-Benzyl-4-[4-(6-methyl-5-nitro-pyridin-2-ylamino)-benzyl]-piperazine-2,3-dione 
• 959801-02-6 6-[5-isopropyl-3-(2-trifluoromethoxy-phenyl)-3H-[1,2,3]triazol-4-ylmethoxy]-2-methyl-3-nitro-pyridine 
• 959631-51-7 6-[4-isopropyl-2-(2-trifluoromethoxy-phenyl)-2H-pyrazol-3-ylmethoxy]-2-methyl-3-nitro-pyridine 
• 329947-26-4 5-amino-6-methyl-2-pyridinesulfonamide 
• 218770-02-6 6-chloro-2-methyl-pyridin-3-ol 
• 132606-40-7 3-bromo-6-chloro-2-methyl-pyridine 
• 123280-64-8 3,6-dichloro-2-methylpyridine 
• 77917-42-1 1-[4-(5-Amino-6-methyl-pyridin-2-ylamino)-benzyl]-4-benzyl-piperazine-2,3-dione 

Relevant articles and documents

Syntheses and pharmacokinetic evaluations of four metabolites of 2-(4-(2-((1H-benzo[d]imidazol-2-yl)thio)ethyl)piperazin-1-yl)-N-(6-methyl-2,4-bis-(methylthio)pyridin-3-yl)acetamide hydrochloride [K-604], an acyl-CoA:cholesterol O-acyltransferase-1 inhibi

We synthesized and identified four metabolites of acyl-coenzyme A:cholesterol O-acyltransferase (ACAT)-1 inhibitor, K-604 (1). Two of the metabolites M1 and M2, were prepared from 1 using a combination reagent of hydrogen peroxide and sodium tungstate wit

Ethanol compound used as FGFR inhibitor

The invention discloses an ethanol compound used as a FGFR inhibitor. The invention provides the compound as shown in a formula I which is described in the specification or a pharmaceutically acceptable salt thereof, a preparation method for the compound and application of the compound as a medicine to treatment of cancers.

Synthesis of some fluorine-containing pyridinealdoximes of potential use for the treatment of organophosphorus nerve-agent poisoning

Fluoroheterocyclic aldoximes were screened as therapeutic agents for the treatment of anticholinesterase poisoning. 2-Fluoropyridine-3- and -6-aldoxime, and 3-fluoropyridine-2- and -4-aldoxime, were synthesised. Attempts to obtain 3,5,6-trifluoropyridine-2,4-bis(aldoxime) and -2-aldoxime, however, proved unsuccessful. Pentafluorobenzaldoxime was prepared by oximation of pentafluorobenzaldehyde. Acid dissociation constants (pKa) and second-order rate constants (kox-) of the fluorinated pyridinealdoximes towards sarin were measured. 2,3,5,6-Tetrafluoropyridine-4- aldoxime had the best profile: its kox- approached that of the therapeutic oxime P2S (310 vs. 120 l mol-1 min-1), but its higher pKa (9.1 vs. 7.8) fell short of the target figure of 8 required for reactivation of inhibited acetylcholinesterase in vivo. N-alkylation of the fluorinated pyridine-aldoximes may reduce their pK a nearer to 8 and enhance their therapeutic potential. Crown Copyright