22282-96-8Relevant articles and documents
Azaindoles: Moderately basic P1 groups for enhancing the selectivity of thrombin inhibitors
Sanderson, Philip E. J.,Stanton, Matthew G.,Dorsey, Bruce D.,Lyle, Terry A.,McDonough, Colleen,Sanders, William M.,Savage, Kelly L.,Naylor-Olsen, Adel M.,Krueger, Julie A.,Lewis, S. Dale,Lucas, Bobby J.,Lynch, Joseph J.,Yan, Youwei
, p. 795 - 798 (2007/10/03)
Starting from a 2-amino-6-methylpyridine P1 group and following a strategy of enlarging it whilst reducing its polarity, we have developed a series of potent, moderately basic azaindoles which are intrinsically much more selective for thrombin versus tryp