222855-48-3

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 222855-47-2 (1aR,7aS)-1,1a,2,7-Tetrahydro-1-aza-cyclopropa[b]naphthalene-7a-carboxylic acid benzyl ester 
• 222855-46-1 2,7-dihydro-1aH-1-oxa-cyclopropa[b]naphthalene-7a-carboxylic acid benzyl ester 
• 222855-45-0 (2,7-dihydro-1aH-1-oxa-cyclopropa[b]naphthalen-7a-yl)-methanol 
• 222855-44-9 (1,4-dihydro-naphthalen-2-yl)-methanol 
• 91-13-4 α,α'-dibromo-o-xylene 
• 82584-13-2 ethyl 1,4-dihydronapthalene-2-carboxylate 

Relevant academic research and scientific papers

Synthesis of orthogonally protected optically pure β-amino acids: Constrained phenylalanine analogs 3-tert-butoxycarbonylamino-1,2,3,4- tetrahydro-2-naphthoic acid benzyl ester

The synthesis of orthogonally protected β-amino acid 3-tert- butoxycarbonylamino-1,2,3,4-tetrahydro-2-naphthoic acid benzyl ester (Boc- βAtc-OBn) is described. The route to these constrained phenylalanine analogs features a SmI2-mediated aziridine cleavage resulting in a β-amino ester. The stereochemistries have been determined by X-ray crystallographic analyses.