22297-70-7

Basic information

• Product Name: sodium 9,10-dihydro-1,4-dihydroxy-9,10-dioxoanthracene-2-sulphonate
• Synonyms: sodium 9,10-dihydro-1,4-dihydroxy-9,10-dioxoanthracene-2-sulphonate;1,4-Dihydroxy-2-(sodiooxysulfonyl)-9,10-anthraquinone;1,4-Dihydroxy-9,10-dioxoanthracene-2-sulfonic acid sodium salt;9,10-Dihydro-1,4-dihydroxy-9,10-dioxo-2-anthracenesulfonic acid sodium salt
• CAS NO: 22297-70-7
• Molecular Formula: C₁₄H₇O₇S*Na
• Molecular Weight: 342.25595
• EINECS: 244-896-3
• Mol File: 22297-70-7.mol
• Article Data: 2

Chemical Properties

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Appearance: /
• Density: 1.792g/cm³
• CAS DataBase Reference: sodium 9,10-dihydro-1,4-dihydroxy-9,10-dioxoanthracene-2-sulphonate(CAS DataBase Reference)
• NIST Chemistry Reference: sodium 9,10-dihydro-1,4-dihydroxy-9,10-dioxoanthracene-2-sulphonate(22297-70-7)
• EPA Substance Registry System: sodium 9,10-dihydro-1,4-dihydroxy-9,10-dioxoanthracene-2-sulphonate(22297-70-7)

Safety Data

• Hazardous Substances Data: 22297-70-7(Hazardous Substances Data)

Usage

InChI:InChI=1/C14H8O7S.Na/c15-8-5-9(22(19,20)21)14(18)11-10(8)12(16)6-3-1-2-4-7(6)13(11)17;/h1-5,15,18H,(H,19,20,21);/q;+1/p-1

Upstream product

• 81-64-1 1,4-dihydroxy-9,10-anthracenedione 

Downstream Products

• 145-48-2 1,4-dihydroxy-9,10-dioxo-9,10-dihydro-anthracene-2-sulfonic acid 

Relevant articles and documents

Sodium 1, 4-dihydroxy-9, 10-anthraquinone- 2-sulphonate interacts with calf thymus DNA in a way that mimics anthracycline antibiotics: An electrochemical and spectroscopic study

The anthracycline drugs, adriamycin and daunorubicin, efficient in the treatment of various human cancers, form strong intercalation complexes with DNA. The therapeutic efficiency and toxic properties of the drugs are associated with electron transfer processes, which correlate well with the redox behaviour of the compounds. Sodium 1,4-dihydroxy 9,10-anthraquinone-2-sulphonate (sodium quinizarin-2-sulphonate, NaLH2) (Na-Qz-2S) is a molecule that resembles anthracycline drugs and has a simpler structure in comparison to these drugs. Two electrons in the course of chemical action reduce this molecule like the anthracyclines. Electrochemical methods were used to identify this process. UV-Vis and fluorescence spectroscopy were used to analyse binding of the compound to calf thymus DNA. The binding constant and site size were evaluated for Na-Qz-2S and the same compared to that of the anthracyclines. Such comparisons are essential in order to understand whether the simpler hydroxy-anthraquinones can be a substitute for anthracycline drugs in cancer chemotherapy. Copyright