222987-24-8

Basic information

• Product Name: 3-(4-CARBOXY-PHENYL)-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
• Synonyms: 3-(4-CARBOXY-PHENYL)-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER;4-(1-(TERT-BUTOXYCARBONYL)PYRROLIDIN-3-YL)BENZOIC ACID;N-BOC-3-(4-CARBOXYPHENYL) PYRROLIDINE;3-(4-carboxyphenyl)-1-Pyrrolidinecarboxylic acid 1-(1,1-dimethylethyl)ester
• CAS NO: 222987-24-8
• Molecular Formula: C₁₆H₂₁NO₄
• Molecular Weight: 291.34
• Mol File: 222987-24-8.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 434.3±45.0 °C(Predicted)
• Appearance: /
• Density: 1.195±0.06 g/cm3(Predicted)
• PKA: 4.31±0.10(Predicted)
• CAS DataBase Reference: 3-(4-CARBOXY-PHENYL)-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-CARBOXY-PHENYL)-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER(222987-24-8)
• EPA Substance Registry System: 3-(4-CARBOXY-PHENYL)-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER(222987-24-8)

Safety Data

• Hazardous Substances Data: 222987-24-8(Hazardous Substances Data)

Usage

General Description

3-(4-carboxy-phenyl)-pyrrolidine-1-carboxylic acid tert-butyl ester, also known as tert-butyl 3-(4-carboxyphenyl)pyrrolidine-1-carboxylate, is a chemical compound commonly used in organic synthesis and pharmaceutical research. It is a tert-butyl ester derivative of pyrrolidine-1-carboxylic acid, containing a carboxylic acid and a phenyl group. 3-(4-CARBOXY-PHENYL)-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER is often used as a building block in the synthesis of various pharmaceuticals and bioactive compounds due to its versatile reactivity and functional groups. Additionally, it has been studied for its potential pharmacological activities and therapeutic uses, particularly in the treatment of neurological and psychiatric disorders.

Upstream product

• 58632-95-4 2-(tert-Butoxycarbonyloxyimino)-2-phenylacetonitrile 

Downstream Products

• 222987-25-9 1-[4-[(3RS)-1-tert-butoxycarbonylpyrrolidin-3-yl]benzoyl]-4-[(6-chloronaphthalen-2-yl)sulfonyl]piperazine 

Relevant articles and documents

NOVEL ETHYLENEDIAMINE DERIVATIVES

A compound represented by the following formula (1):Q-Q-T-N(R)-Q-N(R)-T-Q [wherein, R1 and R2 are hydrogen atoms or the like; Q1 is a saturated or unsaturated, 5- or 6- membered cyclic hydrocarbon group which may have a substituent, or the like; Q2 is a single bond or the like; Q3 represents the following group: -C(R3a)(R4a)-{C(R3b)(R4b)}m1-{C(R3c)(R4c)}m2-{C(R3d)(R4d)}m3-{C(R3e)(R4e)}m4-C(R3f)(R4f)- (in which, R3a to R4e represent hydrogen or the like); T0 represents a carbonyl group or the like; and T1 represents -COCONR- or the like]; or salt thereof, solvate thereof, or N-oxide thereof. The compound is useful as a preventive and/or therapeutic agent for cerebral infarction, cerebral embolism, myocardial infarction, angina pectoris, pulmonary infarction, pulmonary embolism, Buerger's disease, deep venous thrombosis, disseminated intravascular coagulation syndrome, thrombus formation after valve or joint replacement, thrombus formation and reocclusion after angioplasty, systemic inflammatory response syndrome (SIRS), multiple organ dysfunction syndrome (MODS), thrombus formation during extracorporeal circulation, or blood clotting upon blood drawing.

NOVEL SULFONYL DERIVATIVES

Sulfonyl derivatives represented by the following general formula (I): Q1-Q2-T1-Q3-SO2-QA and drugs containing the same (wherein Q1 is an optionally substituted, saturated or unsaturated, five- or six-membered cyclic hydrocarbon group, a five- or six-membered heterocyclic group, or the like; Q2 is a single band, oxygen, sulfur, C1-C6 alkylene or the like; QA is optionally substituted arylalkenyl, heteroarylalkenyl or the like; and T1 is carbonyl or the like). These compounds have potent FXa-inhibitory effects and promptly exert satisfactory and persistent antithrombotic effects through oral administration, thus being useful as anticoagulant agents little accompanied with side effects.