22307-72-8

Usage

Uses

Used in Chemical Synthesis:
TETRA-N-BUTYLAMMONIUM SALICYLATE is used as a phase-transfer catalyst for facilitating the transfer of reactants between immiscible phases in a reaction. This property makes it useful in various chemical processes, enhancing the efficiency and selectivity of the reactions.
Used in Pharmaceutical Industry:
TETRA-N-BUTYLAMMONIUM SALICYLATE is used as an anti-inflammatory agent in pharmaceuticals due to its ability to reduce pain and inflammation. The presence of the salicylate moiety contributes to its anti-inflammatory properties, making it a potential ingredient in medications for treating various inflammatory conditions.

Upstream product

• 2052-49-5 tetra(n-butyl)ammonium hydroxide 
• 69-72-7 salicylic acid 

Relevant academic research and scientific papers

Delineation of the Critical Parameters of Salt Catalysts in the N-Formylation of Amines with CO2

N-formylation of amines combining CO2 as a C1 source with a hydrosilane reducing agent is a convenient route for the synthesis of N-formylated compounds. A large number of salts including ionic liquids (ILs) have been shown to efficiently catalyze the reaction and, yet, the key features of the catalyst remain unclear and the best salt catalysts for the reaction remain unknown. Here we demonstrate the detrimental effect of ion pairing on the catalytic activity and illustrate ways in which the strength of the interaction between the ions can be reduced to enhance interactions and, hence, reactivity with the substrates. In contrast to the current hypothesis, we also show that salt catalysts are more active as bases rather than nucleophiles and identify the pKa where the nucleophilic role of the catalyst switches to the more active basic role. The identification of these critical parameters allows the optimum salt catalyst and conditions for an N-formylation reaction to be predicted.

Acidity of ortho-substituted benzoic acids: An infrared and theoretical study of the intramolecular hydrogen bonds

The structures of ortho-substituted benzoic acids with substituents bearing hydrogen atoms (OH, NH2, COOH and SO2NH2) were investigated by means of IR spectroscopy and of density functional theory at the B3LYP/6-311 + G(d,p) level. All possible conformations, hydrogen bonds, tautomeric forms and zwitterions were taken into consideration and particular attention was given to intramolecular H-bonds and their effect on acidity. Strong H-bonds in the anions of all four acids, were revealed by calculations. In three cases they were confirmed by the IR spectra of the tetrabutylammonium salts in tetrachloromethane solution, while the salt of 1,2-benzenedicarboxylic acid was not sufficiently soluble. The H-bonds are of different strengths but in all cases they are the main cause of the strengthened acidity of these acids in the gas phase and also in solution, although their effect is opposed by weaker H-bonds present in the undissociated acid molecules. The substituent effect on the acidity was evaluated in terms of isodesmic reactions, separately in the acid molecules and in the anions. While the acidity of the 2-OH and 2-NH 2 acids is determined essentially by the H-bonds, that of the 2-COOH and 2-SO2NH2 acids is strengthened by the polar effect operating in the undissociated molecule in addition to the H-bond in the anion. The steric inhibition of resonance (SIR), estimated from model conformations with fixed torsional angles, is of little importance. This analysis goes significantly beyond the classical explanation obtained from the acidities in solution but essentially conforms with it. The Royal Society of Chemistry 2006.