223105-98-4Relevant academic research and scientific papers
Structure elucidation and chiral-total synthesis of a new indole alkaloid, (-)-9-methoxymitralactonine, isolated from Mitragyna speciosa in Malaysia
Takayama, Hiromitsu,Kurihara, Mika,Kitajima, Mariko,Said, Ikram M.,Aimi, Norio
, p. 3145 - 3151 (2007/10/03)
A new Corynanthe-type indole alkaloid, (-)-9-methoxymitralactonine (1), having a highly conjugated system was isolated from the young leaves of Mitragyna speciosa in Malaysia, and its structure was first deduced by spectroscopic analysis and then confirmed by chiral-total synthesis starting from optically pure epoxy-ketone and 5-methoxy-3,4-dihydro-β-carboline. The chiral HPLC analysis demonstrated that the natural 9-methoxymitralactonine contained predominantly the (-)-enantiomer over the (+)-enantiomer in the ratio of 62:38. (C) 2000 Elsevier Science Ltd.
