22319-19-3

Basic information

• Product Name: (E)-2-(hydroxyimino)-1-(4-hydroxyphenyl)propan-1-one
• Synonyms: (E)-2-(hydroxyimino)-1-(4-hydroxyphenyl)propan-1-one
• CAS NO: 22319-19-3
• Molecular Weight: 179.175
• Mol File: 22319-19-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (E)-2-(hydroxyimino)-1-(4-hydroxyphenyl)propan-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-2-(hydroxyimino)-1-(4-hydroxyphenyl)propan-1-one(22319-19-3)
• EPA Substance Registry System: (E)-2-(hydroxyimino)-1-(4-hydroxyphenyl)propan-1-one(22319-19-3)

Safety Data

• Hazardous Substances Data: 22319-19-3(Hazardous Substances Data)

Upstream product

• 70-70-2 4-hydroxypropiophenone 
• 544-16-1 n-Butyl nitrite 

Downstream Products

• 99-96-7 4-hydroxy-benzoic acid 

Relevant articles and documents

Synthesis of Acyl Fluorides via DAST-Mediated Fluorinative C-C Bond Cleavage of Activated Ketones

A new protocol for preparation of acyl fluorides was developed by recognizing activated ketones as starting materials. The method provides a different scope compared with previously reported methods that employ carboxylic acids as substrates. A working hypothesis of pull-and-push-driven fluorinative C-C bond cleavage was successfully demonstrated by the simple addition of diethylaminosulfur trifluoride (DAST) derivatives to α-oximinoketones. The designed reaction system led to a highly efficient and chemoselective reaction. The wide availability of the ketones allowed for a range of synthetically useful aryloyl and aliphatic acyl fluorides including those containing chiral skeletons. The method is mild, fast, scalable, and potentially one-pot operative.