223253-14-3

Basic information

• Product Name: 2-Piperidinone, 1-[[5-[[4-[2-(1-methylethoxy)phenyl]-1-piperazinyl]methyl]-1H-pyrazol-3-yl ]methyl]-
• CAS NO: 223253-14-3
• Molecular Formula: C23H33N5O2
• Molecular Weight: 411.547
• Mol File: 223253-14-3.mol

Chemical Properties

• CAS DataBase Reference: 2-Piperidinone, 1-[[5-[[4-[2-(1-methylethoxy)phenyl]-1-piperazinyl]methyl]-1H-pyrazol-3-yl ]methyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Piperidinone, 1-[[5-[[4-[2-(1-methylethoxy)phenyl]-1-piperazinyl]methyl]-1H-pyrazol-3-yl ]methyl]-(223253-14-3)
• EPA Substance Registry System: 2-Piperidinone, 1-[[5-[[4-[2-(1-methylethoxy)phenyl]-1-piperazinyl]methyl]-1H-pyrazol-3-yl ]methyl]-(223253-14-3)

Safety Data

• Hazardous Substances Data: 223253-14-3(Hazardous Substances Data)

Upstream product

• 223253-61-0 1-[4-(2-isopropoxy-phenyl)-piperazin-1-yl]-propan-2-one 
• 54013-91-1 2-(1-methylethoxy)phenyl-1-piperazine 
• 675-20-7 piperidin-2-one 
• 223253-54-1 1-[4-(2-isopropoxy-phenyl)-piperazin-1-yl]-5-(2-oxo-piperidin-1-yl)-pentane-2,4-dione 

Relevant articles and documents

Novel heterocycles as selective α1-adrenergic receptor antagonists

A novel series of aryl piperazine substituted heterocycles has been synthesized and identified as antagonists of the α(1a)-adrenergic receptor (α(1a)-AR), which has been implicated in benign prostatic hyperplasia (BPH). These compounds selectively inhibit binding to the α(1a)-AR with K(i)s as low as 2.1 nM. (C) 2000 Elsevier Science Ltd.

Heterocycles useful in the treatment of benign prostatic hyperplasia

This invention relates a to a series of heterocyclic substituted piperazines of Formula I pharmaceutical compositions containing them and intermediates used in their manufacture. The compounds of the invention selectively inhibit binding to the α-1a adrenergic receptor, a receptor which has been implicated in benign prostatic hyperplasia. As such the compounds are potentially useful in the treatment of this disease.