223253-87-0

Basic information

• Product Name: 4-[2-(2,2,2-trifluoroacetamido)ethyl]benzenesulfonyl chloride
• Synonyms: 4-[2-(2,2,2-trifluoroacetamido)ethyl]benzenesulfonyl chloride
• CAS NO: 223253-87-0
• Molecular Weight: 315.701
• Mol File: 223253-87-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-[2-(2,2,2-trifluoroacetamido)ethyl]benzenesulfonyl chloride(CAS DataBase Reference)
• NIST Chemistry Reference: 4-[2-(2,2,2-trifluoroacetamido)ethyl]benzenesulfonyl chloride(223253-87-0)
• EPA Substance Registry System: 4-[2-(2,2,2-trifluoroacetamido)ethyl]benzenesulfonyl chloride(223253-87-0)

Safety Data

• Hazardous Substances Data: 223253-87-0(Hazardous Substances Data)

Upstream product

• 64-04-0 phenethylamine 
• 458-85-5 2,2,2-trifluoro-N-(2-phenylethyl)acetamide 

Downstream Products

• 16673-34-0 5-chloro-2-methoxy-N-(4-sulfamoylphenethyl)benzamide 
• 10238-21-8 Glibenclamid 
• 35303-76-5 4-(2-aminoethyl)benzenesulfonamide 
• 477259-00-0 2,2,2-trifluoro-N-[2-(4-mercaptophenyl)ethyl]acetamide 
• 699015-68-4 methyl [2-methoxy-5-[(4-[2-[(trifluoroacetyl)-amino]ethyl]phenyl]sulfonyl]phenyl]acetate 

Relevant articles and documents

Synthesis method of glibenclamide

The invention discloses a synthesis method of glibenclamide, which includes the steps of: 1) protection of amino groups with trichloroacetic anhydride; 2) sulfonation; 3) sulfo-amidation; 4) amidation: performing a reaction to 5-chloro-2-methoxybenzoic acid with N,N-carbonyl diimidazole and performing a reaction to the product with a compound (III) under effect of a second acid-binding agent; 5) addition: adding the second acid-binding agent and crown ether, in catalytic amount, to perform an addition reaction to a compound (IV) with cyclohexyl isocyanate to prepare the glibenclamide. The method is high in yields in all steps, wherein residue of impurities is effectively reduced during processes of protection, deprotection, acid treatment, alkali treatment and water-adding separation of the substrate. According to the method, a phase-transfer catalyst is matched with the second acid-binding agent, so that compatibility between the isocyanate and the compound (IV) is effectively increased, and the nucleophilic reaction is carried out more completely. The produced product is higher in purity.