223254-23-7

Upstream product

• 223254-19-1 4-((tert-butyldiphenylsilyloxy)methyl)thiophene-2-carbaldehyde 
• 125849-86-7 tert-butyldiphenyl(thiophen-3-ylmethoxy)silane 
• 71637-34-8 3-hydroxymethyl-thiophene 
• 223254-21-5 1-[4-(tert-butyl-diphenyl-silanyloxymethyl)-thiophen-2-ylmethyl]-4-(2-isopropoxy-phenyl)-piperazine 

Relevant academic research and scientific papers

Novel thiophene derivatives for the treatment of benign prostatic hyperplasia

The syntheses and biological activities of a novel series of 2,4- and 2,5-disubstituted thiophenes are reported. These analogues have shown excellent affinity and selectivity against α1-adrenoreceptor subtypes.

Heterocycles useful in the treatment of benign prostatic hyperplasia

This invention relates a to a series of heterocyclic substituted piperazines of Formula I pharmaceutical compositions containing them and intermediates used in their manufacture. The compounds of the invention selectively inhibit binding to the α-1a adrenergic receptor, a receptor which has been implicated in benign prostatic hyperplasia. As such the compounds are potentially useful in the treatment of this disease.