223266-68-0

Basic information

• Product Name: 2(R)-(2-Benzothiazolylmethyl)-N-methyl-4-oxo-N-[4-(trifluoromethyl)benzyl]azetidine-1-carboxamide
• CAS NO: 223266-68-0
• Molecular Formula: C₂₁H₁₈F₃N₃O₂S
• Molecular Weight: 433.45571
• Mol File: 223266-68-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2(R)-(2-Benzothiazolylmethyl)-N-methyl-4-oxo-N-[4-(trifluoromethyl)benzyl]azetidine-1-carboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2(R)-(2-Benzothiazolylmethyl)-N-methyl-4-oxo-N-[4-(trifluoromethyl)benzyl]azetidine-1-carboxamide(223266-68-0)
• EPA Substance Registry System: 2(R)-(2-Benzothiazolylmethyl)-N-methyl-4-oxo-N-[4-(trifluoromethyl)benzyl]azetidine-1-carboxamide(223266-68-0)

Safety Data

• Hazardous Substances Data: 223266-68-0(Hazardous Substances Data)

Upstream product

• 250135-80-9 (4R)-4-[(benzothiazol-2-yl)methyl]-1-(triisopropylsilanyl)azetidin-2-one 
• 211619-44-2 N-Methyl-N-{{4-(trifluoromethyl)phenyl}methyl}carbamoyl chloride 
• 250135-85-4 (4R)-4-[(benzothiazol-2-yl)methyl]azetidin-2-one 

Relevant articles and documents

Synthesis and antiviral activity of monobactams inhibiting the human cytomegalovirus protease

A series of monobactam inhibitors of HCMV (N(o)) protease bearing a heterocycle linked by a methylene group at C-4 is described. Inhibitors containing a heterocycle such as a 2-furyl, 2-thiophenyl, 4-methyl-2-tetrazole and 2-benzothiazole were found to be active in a plaque reduction assay. Furthermore, 2-benzothiazole derivatives were shown to inhibit the HCMV protease activity inside cells by using a cell transfection assay, indicating that their antiviral activity in the plaque reduction assay could be attributed to protease inhibition. Copyright (C) 1999 Elsevier Science Ltd.