22333-59-1Relevant academic research and scientific papers
Effect of 9-hydroxy-α-and 7-hydroxy-β-pyran naphthoquinones on trypanosoma cruzi and structure-Activity relationship studies
Da Rocha, David R.,De Souza, Alessandra M.T.,De Souza, Ana Carolina G.,Castro, Helena C.,Rodrigues, Carlos R.,Menna-Barreto, Rubem F.S.,De Castro, Solange L.,Ferreira, Vitor F.
, p. 564 - 570 (2014/11/08)
The available treatment for the prevention and cure of Chagas disease, caused by the protozoan Trypanosoma cruzi, is still unsatisfactory. Thus, there is an urgent need to develop new drugs. In the last few years, our research group has focused on finding
β-Lapachone analogs with enhanced antiproliferative activity
Rios-Luci, Carla,Bonifazi, Evelyn L.,Leon, Leticia G.,Montero, Juan C.,Burton, Gerardo,Pandiella, Atanasio,Misico, Rosana I.,Padron, Jose M.
experimental part, p. 264 - 274 (2012/08/28)
In this study, we describe the synthesis of a series of α- and β-lapachone containing hydroxyl or methoxyl groups on the benzene ring, by means of the selective acid promoted cyclization of the appropriate lapachol analog. The evaluation of the antiproliferative activity in human solid tumor cell lines provided 7-hydroxy-β-lapachone as lead with enhanced activity over the parent drug β-lapachone. Cell cycle studies, protein expression experiments, and reactive oxygen species analysis revealed that, similarly to β-lapachone, ROS formation and DNA damage are critical factors in the cellular toxicity of 7-hydroxy-β-lapachone.
Synthesis of new 9-hydroxy-α- and 7-hydroxy-β-pyran naphthoquinones and cytotoxicity against cancer cell lines
Da Rocha, David R.,De Souza, Ana C. G.,Resende, Jackson A. L. C.,Santos, Wilson C.,Dos Santos, Evelyne A.,Pessoa, Claudia,De Moraes, Manoel O.,Costa-Lotufo, Leticia V.,Montenegro, Raquel C.,Ferreira, Vitor F.
, p. 4315 - 4322 (2011/07/08)
A synthetic method to obtain α- and β-pyran naphthoquinones 10 and 11 with a hydroxyl substituent on the aromatic ring was developed. Two series of α- and β-pyran naphthoquinones were obtained from the 8-hydroxy-lawsone, and their anticancer properties we
