22338-71-2

Basic information

• Product Name: Polygalacic acid
• Synonyms: Polygalacic acid;Polygalacic;(2b,3b,4a,16a)-2,3,16,23-Tetrahydroxyolean-12-en-28-oic acid;Olean-12-en-28-oicacid, 2,3,16,23-tetrahydroxy-, (2β,3β,4,16)-;Virgaureagenin G;(4R)-2β,3β,16α,23-Tetrahydroxyolean-12-en-28-oic acid;Polygalacic acid or (2b,3b,4a,16a)-2,3,16,23-Tetrahydroxyolean-12-en-28-oic acid;Polygalacic acid (2b,3b,4a,16a)-2,3,16,23-Tetrahydroxyolean-12-en-28-oic acid
• CAS NO: 22338-71-2
• Molecular Formula: C₃₀H₄₈O₆
• Molecular Weight: 504.7
• Product Categories: chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract
• Mol File: 22338-71-2.mol
• Article Data: 4

Chemical Properties

• Melting Point: 300-305 °C (sublm)
• Boiling Point: 638.1 °C at 760 mmHg
• Flash Point: 353.7 °C
• Appearance: /
• Density: 1.23 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.593
• PKA: 4.41±0.70(Predicted)
• CAS DataBase Reference: Polygalacic acid(CAS DataBase Reference)
• NIST Chemistry Reference: Polygalacic acid(22338-71-2)
• EPA Substance Registry System: Polygalacic acid(22338-71-2)

Safety Data

• Hazardous Substances Data: 22338-71-2(Hazardous Substances Data)

Usage

General Description

Polygalacic acid is a natural triterpene compound found in the roots of Polygala tenuifolia, a traditional Chinese medicinal herb. It has been shown to possess various pharmacological properties, including anti-inflammatory, neuroprotective, and antidepressant effects. Polygalacic acid has been studied for its potential in treating chronic inflammatory conditions, such as rheumatoid arthritis, and for its ability to enhance cognitive function and alleviate symptoms of depression. Additionally, research has indicated that it may have antioxidant and anti-cancer properties. Overall, polygalacic acid is a promising compound with therapeutic potential for various health conditions.

InChI:InChI=1/C30H48O6/c1-25(2)11-12-30(24(35)36)18(13-25)17-7-8-21-26(3)14-19(32)23(34)27(4,16-31)20(26)9-10-28(21,5)29(17,6)15-22(30)33/h7,18-23,31-34H,8-16H2,1-6H3,(H,35,36)/t18-,19-,20+,21+,22+,23-,26-,27-,28+,29+,30+/m0/s1

Upstream product

• 1192501-87-3 3-O-β-D-glucopyranosyl-(1->3)-β-D-glucopyranosyl-2β,3β,16α,23-tetrahydroxyolean-12-en-28-oic acid 28-O-α-L-rhamnopyranosyl-(1->3)-β-D-xylopyranosyl-(1->4)-[β-D-apiosyl-(1->3)]-α-L-rhamnopyranosyl-(1->2)-α-L-arabinopyranoside 
• 1192501-86-2 3-O-β-D-glucopyranosyl-(1->3)-β-D-glucopyranosyl-2β,3β,16α,23-tetrahydroxyolean-12-en-28-oic acid 28-O-α-L-rhamnopyranosyl-(1->3)-β-D-xylopyranosyl-(1->4)-α-L-rhamnopyranosyl-(1->2)-α-L-arabinopyranoside 
• 1033766-69-6 polygalacic acid 28-O-α-L-rhamnopyranosyl(1->3)-β-D-xylopyranosyl(1->4)-2-O-acetyl-α-L-rhamnopyranosyl(1->2)-4-O-acetyl-β-D-fucopyranoside 
• 1033766-70-9 perennisaponin B 
• 113929-41-2 crocosmioside A 

Downstream Products

• 22338-72-3 methyl polygalacate 

Relevant articles and documents

Acylated oleanane-type triterpene saponins from the flowers of Bellis perennis show anti-proliferative activities against human digestive tract carcinoma cell lines

Seven oleanane-type triterpene saponin bisdesmosides, perennisaponins N–T (1–7), were newly isolated from a methanol extract of daisy, the flowers of Bellis perennis L. (Asteraceae). The structures were determined based on chemical and physicochemical data and confirmed using previously isolated related compounds as references. The isolates, including 13 previously reported perennisaponins A–M (8–20), exhibited anti-proliferative activities against human digestive tract carcinoma HSC-2, HSC-4, and MKN-45 cells. Among them, perennisaponin O (2, IC50?=?11.2, 14.3, and 6.9?μM, respectively) showed relatively strong activities. The mechanism of action of 2 against HSC-2 was found to involve apoptotic cell death.

Medicinal flowers. XXI.1) Structures of perennisaponins A, B, C, D, E, and F, acylated oleanane-type triterpene oligoglycosides, from the flowers of Bellis perennis

Six new acylated oleanane-type triterpene oligoglycosides, perennisaponins A (1), B (2), C (3), D (4), E (5), and F (6), were isolated from the flowers of Bellis perennis (Daisy flower) together with 14 saponins, nine flavonoids, and two glycosides. The structures of 1-6 were elucidated on the basis of chemical and physicochemical evidence.