22338-71-2

Usage

Uses

Used in Pharmaceutical Industry:
Polygalacic acid is used as an anti-inflammatory agent for treating chronic inflammatory conditions, such as rheumatoid arthritis, due to its ability to reduce inflammation and alleviate pain.
Used in Neurological Applications:
Polygalacic acid is used as a neuroprotective agent to enhance cognitive function and protect the nervous system from damage, making it a potential treatment for neurodegenerative diseases.
Used in Mental Health Applications:
Polygalacic acid is used as an antidepressant to alleviate symptoms of depression by modulating neurotransmitter levels and promoting a positive mood.
Used in Antioxidant Applications:
Polygalacic acid is used as an antioxidant to neutralize free radicals and protect cells from oxidative stress, which may contribute to aging and various diseases.
Used in Anticancer Applications:
Polygalacic acid is used as a potential anti-cancer agent due to its ability to inhibit cancer cell growth and induce apoptosis, making it a candidate for cancer prevention and treatment.

InChI:InChI=1/C30H48O6/c1-25(2)11-12-30(24(35)36)18(13-25)17-7-8-21-26(3)14-19(32)23(34)27(4,16-31)20(26)9-10-28(21,5)29(17,6)15-22(30)33/h7,18-23,31-34H,8-16H2,1-6H3,(H,35,36)/t18-,19-,20+,21+,22+,23-,26-,27-,28+,29+,30+/m0/s1

Upstream product

• 113929-41-2 crocosmioside A 
• 1033766-70-9 perennisaponin B 
• 1033766-69-6 polygalacic acid 28-O-α-L-rhamnopyranosyl(1->3)-β-D-xylopyranosyl(1->4)-2-O-acetyl-α-L-rhamnopyranosyl(1->2)-4-O-acetyl-β-D-fucopyranoside 
• 1192501-87-3 3-O-β-D-glucopyranosyl-(1->3)-β-D-glucopyranosyl-2β,3β,16α,23-tetrahydroxyolean-12-en-28-oic acid 28-O-α-L-rhamnopyranosyl-(1->3)-β-D-xylopyranosyl-(1->4)-[β-D-apiosyl-(1->3)]-α-L-rhamnopyranosyl-(1->2)-α-L-arabinopyranoside 
• 1192501-86-2 3-O-β-D-glucopyranosyl-(1->3)-β-D-glucopyranosyl-2β,3β,16α,23-tetrahydroxyolean-12-en-28-oic acid 28-O-α-L-rhamnopyranosyl-(1->3)-β-D-xylopyranosyl-(1->4)-α-L-rhamnopyranosyl-(1->2)-α-L-arabinopyranoside 

Downstream Products

• 22338-72-3 methyl polygalacate 

Relevant academic research and scientific papers

Acylated oleanane-type triterpene saponins from the flowers of Bellis perennis show anti-proliferative activities against human digestive tract carcinoma cell lines

Seven oleanane-type triterpene saponin bisdesmosides, perennisaponins N–T (1–7), were newly isolated from a methanol extract of daisy, the flowers of Bellis perennis L. (Asteraceae). The structures were determined based on chemical and physicochemical data and confirmed using previously isolated related compounds as references. The isolates, including 13 previously reported perennisaponins A–M (8–20), exhibited anti-proliferative activities against human digestive tract carcinoma HSC-2, HSC-4, and MKN-45 cells. Among them, perennisaponin O (2, IC50?=?11.2, 14.3, and 6.9?μM, respectively) showed relatively strong activities. The mechanism of action of 2 against HSC-2 was found to involve apoptotic cell death.

New saponins from Sechium mexicanum

The chemical study of Sechium mexicanum roots led to the isolation of the two new saponins {3-0-β-d-glucopyranosyl (1→3)-β-d- glucopyranosyl-2β,3β,16α,23-tetrahydroxyolean-12-en-28-oic acid 28-0-α-l-rhamnopyranosyl-(1→3)-β-d- xylopyranosyl-(1→4)- α-l-rham

Medicinal flowers. XXI.1) Structures of perennisaponins A, B, C, D, E, and F, acylated oleanane-type triterpene oligoglycosides, from the flowers of Bellis perennis

Six new acylated oleanane-type triterpene oligoglycosides, perennisaponins A (1), B (2), C (3), D (4), E (5), and F (6), were isolated from the flowers of Bellis perennis (Daisy flower) together with 14 saponins, nine flavonoids, and two glycosides. The structures of 1-6 were elucidated on the basis of chemical and physicochemical evidence.

NOVEL ACYLATED SAPONINS, CROCOSMIOSIDES A AND B, FROM MONTBRETIA (CROCOSMIA CROCOSMIIFLORA)

Two novel triterpenoid saponins, named crocosmiosides A (1) and B (2) were isolated from montbretia, and their stuctures were elucidated on the basis of spectral and chemical evidence.They are the first examples of saponins containing hydroxylated palmitic acid derivatives as acyl moieties.KEYWORDS - Crocosmia crocosmiiflora; Montbretia; Iridaceae; crocosmioside A; crocosmioside B; acylated saponin; 13C-NMR