223387-06-2Relevant academic research and scientific papers
Solid-phase synthesis of novel inhibitors of Farnesyl Transferase
Barber, Amelia Moreno,Hardcastle, Ian R.,Rowlands, Martin G.,Nutley, Bernard P.,Marriott, Jonathan H.,Jarman, Michael
, p. 623 - 626 (2007/10/03)
A novel diphosphate mimic, the 2,3,6-trifluoro-5-hydroxy-4-nitrophenoxy group (1), has been employed as the template in the solid-phase synthesis of novel Farnesyl Transferase inhibitors using the Mitsunobu reaction. The most potent inhibitor (famesyloxy-
