223440-06-0Relevant academic research and scientific papers
Synthesis of new 3,4,5-trisubstituted isothiazoles as effective inhibitory agents of enteroviruses
Cutri, Christian C. C.,Garozzo, Adriana,Siracusa, Maria A.,Sarva, Maria C.,Castro, Angelo,Geremia, Ernesto,Pinizzotto, Maria R.,Guerrera, Francesco
, p. 225 - 230 (2007/10/03)
The synthesis and evaluation of 3,4,5-trisubstituted isothiazoles as antiviral agents led to the discovery of several compounds effective in vitro against enteroviruses polio 1 and ECHO 9. Structure-activity relationship studies revealed that a short thioalkyl chain in the 3-position and a methyl ester group in the 4-position are the structural components that, to a large extent, contribute to the positive biological profile in terms of both selectivity and low cytotoxicity. Under one-step growth conditions, methyl 3-methylthio-5-phenyl-4-isothiazolecarboxilate caused the greatest activity if added within 1h after poliovirus adsorption. These data suggest interference with early events of viral replication. Copyright (C) 1999 Elsevier Science Ltd.
