223444-56-2Relevant academic research and scientific papers
A Visible-Light-Driven, Metal-free Route to Aromatic Amides via Radical Arylation of Isonitriles
Malacarne, Marco,Protti, Stefano,Fagnoni, Maurizio
supporting information, p. 3826 - 3830 (2017/11/15)
The photochemical metal-free carboamidation of aryl radicals has been exploited for the preparation of aromatic amides, including hetero- and polyaromatic derivatives, under visible light irradiation of arylazo sulfones in the presence of isocyanides in aqueous acetonitrile. The process was useful for the smooth preparation of the antidepressant moclobemide. (Figure presented.).
Amide derivative
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, (2008/06/13)
A compound of the formula: wherein Ar is optionally substituted phenyl, etc.; n is 0, 1 or 2; R1is hydogen atom, optionally substituted alkyl, etc.; R2and R3are independently optionally substituted alkyl, etc.; R4and R5are independently hydrogen atom or optionally substituted alkyl; R6is hydrogen atom, hydroxy or alkyl; or a pharmaceutically acceptable salt thereof is useful as a medicament for treating retinal degenerative disorders and the like.
