223472-31-9 Usage
Uses
MMP Inhibitor V is a broad-spectrum inhibitor of matrix metalloproteinase (MMPs).
Biological Activity
Broad spectrum MMP inhibitor; K i values are 0.45, 0.73, 1.1, 1.1, 2.1, 42 and 2500 nM for MMP-12, MMP-2, MMP-8, MMP-13, MMP-9, MMP-3 and MMP-7 respectively and IC 50 = 1600 nM for MMP-1). Displays no activity at other proteases up to a concentration of 100 μ M. Exhibits antiangiogenic and anti-invasive properties on lung metastasis of murine renal cell carcinoma.
references
[1]. okamoto, y., et al., a matrix metalloproteinase inhibitor, ono-4817, suppresses the development of aortic intimal hyperplasia in experimental hyperlipidemic rabbit. int heart j, 2007. 48(3): p. 369-78.[2]. shiraga, m., et al., organ heterogeneity of host-derived matrix metalloproteinase expression and its involvement in multiple-organ metastasis by lung cancer cell lines. cancer res, 2002. 62(20): p. 5967-73.[3]. ro, y., et al., inhibitory effects of matrix metalloproteinase inhibitor ono-4817 on morphological alterations in chlorhexidine gluconate-induced peritoneal sclerosis rats. nephrol dial transplant, 2007. 22(10): p. 2838-48.
Check Digit Verification of cas no
The CAS Registry Mumber 223472-31-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,2,3,4,7 and 2 respectively; the second part has 2 digits, 3 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 223472-31:
(8*2)+(7*2)+(6*3)+(5*4)+(4*7)+(3*2)+(2*3)+(1*1)=109
109 % 10 = 9
So 223472-31-9 is a valid CAS Registry Number.
