223477-44-9Relevant academic research and scientific papers
Synthesis of some novel 1-aminomethyl-3-benzoylhydrazono-2-indolinones as potential antiinflammatory agents
Nagarapu, Lingaiah,Ravirala, Narender,Akkewar, Dattatray M.
, p. 1254 - 1257 (2007/10/03)
Acid-catalysed condensation of hydrazides 3, obtained from substituted phenoxybenzoic acids 1 with indolin-2,3-dione 4, results into hydrazono-2-indolinones 5. Compounds 5 when subjected to Mannich reaction with different cyclic secondary amines yield 1-aminomethyl-3-benzoylhydrazono-2-indolinones 6 (Mannich bases). All these compounds (6a-i) exhibit significant antiinflammatory activity.
