223482-25-5Relevant academic research and scientific papers
Synthesis and electrochemistry of 2-ethenyl and 2-ethanyl derivatives of 5-nitroimidazole and antimicrobial activity against Giardia lamblia
Valdez, Carlos A.,Tripp, Jonathan C.,Miyamoto, Yukiko,Kalisiak, Jaroslaw,Hruz, Petr,Andersen, Yolanda S.,Brown, Sabrina E.,Kangas, Karina,Arzu, Leo V.,Davids, Barbara J.,Gillin, Frances D.,Upcroft, Jacqueline A.,Upcroft, Peter,Fokin, Valery V.,Smith, Diane K.,Sharpless, K. Barry,Eckmann, Lars
experimental part, p. 4038 - 4053 (2009/12/28)
Infections with the diarrheagenic pathogen, Giardia lamblia, are commonly treated with the 5-nitroimidazole (5-NI) metronidazole (Mz), and yet treatment failures and Mz resistance occur. Using a panel of new 2-ethenyl and 2-ethanyl 5-NI derivatives, we fo
Competition between C- and O-alkylation reactions in 5-nitroimidazole series: Influence of nucleophile
Benakli, Kamel,Kaafarani, Mustapha,Crozet, Michel P.,Vanelle, Patrice
, p. 557 - 565 (2007/10/03)
The new reductive alkylating agent, 2-(4-chloromethylstyryl)-1-methyl- 5-nitro-1H-imidazole gives exclusively O-alkylation with 2-nitropropane anion. The electron-transfer C-alkylation is observed with the anions of ethyl 2-nitropropionate and dialkyl α-s
