223500-33-2Relevant academic research and scientific papers
Allosteric modulators of the AMPA receptor: Novel 6-substituted dihydrophthalazines
Pei, Xue-Feng,Sturgess, Michael A.,Fernando Valenzuela,Maccecchini, Maria-Luisa
, p. 539 - 542 (2007/10/03)
Novel analogs of the allosteric AMPA receptor modulator SYM 2206 have been prepared. Structure/activity correlations of these novel analogs and other dihydrophthalazines (DHPs) reveal the important contribution of the heteroatom-based aryl substituents in this class of noncompetitive inhibitors. One of the analogs (6, SYM 2189) is equipotent with the early series, but with reduced sedation.
