22352-81-4

Basic information

• Product Name: Norfentanyl Hydrochloride
• Synonyms: Norfentanyl Hydrochloride;4-(N-Propionanilido)piperidine Hydrochloride;N-[Piperidin-4-yl]-N-phenylpropionaMide Hydrochloride;N-4-Piperidylpropionanilide Hydrochloride;N-Phenyl-N-(4-piperidinyl)propanaMide Hydrochloride;N-Phenyl-N-4-piperidinylpropionaMide Hydrochloride
• CAS NO: 22352-81-4
• Molecular Formula: C14H21ClN2O
• Molecular Weight: 268.78234
• Product Categories: Amines;Aromatics;Intermediates & Fine Chemicals;Metabolites & Impurities;Pharmaceuticals
• Mol File: 22352-81-4.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• Storage Temp.: Hygroscopic, -20°C Freezer, Under Inert Atmosphere
• Stability: Hygroscopic
• CAS DataBase Reference: Norfentanyl Hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: Norfentanyl Hydrochloride(22352-81-4)
• EPA Substance Registry System: Norfentanyl Hydrochloride(22352-81-4)

Safety Data

• Hazardous Substances Data: 22352-81-4(Hazardous Substances Data)

Usage

Chemical Properties

White to Off-White Solid

Uses

Major hepatic metabolite of Fentanyl (F274990).

Upstream product

• 62-53-3 aniline 
• 3612-20-2 1-phenylmethyl-4-piperidone 
• 1474-02-8 N-(1-benzyl-4-piperidinyl)-N-phenylpropionamide 

Downstream Products

• 1586819-16-0 C₂₈H₃₂N₄O 

Relevant articles and documents

A photochromic agonist for μ-opioid receptors

Opioid receptors (ORs) are widely distributed in the brain, the spinal cord, and the digestive tract and play an important role in nociception. All known ORs are G-protein-coupled receptors (GPCRs) of family A. Another well-known member of this family, rhodopsin, is activated by light through the cis/trans isomerization of a covalently bound chromophore, retinal. We now show how an OR can be combined with a synthetic azobenzene photoswitch to gain light sensitivity. Our work extends the reach of photopharmacology and outlines a general strategy for converting Family A GPCRs, which account for the majority of drug targets, into photoreceptors. Lighting up the opioid receptor: Photofentanyl-2 is a photochromic version of the well-known analgesic fentanyl. It is a potent agonist in the dark (or when illuminated with blue light) and loses activity when irradiated with UV light. It can be used to optically control the μ-opioid receptor, converting a G-protein-coupled receptor (GPCR) into a photoreceptor.