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3-N-Maleimidobenzohydrazide-HCl is a chemical compound that features a maleimide group and a hydrazide group attached to a benzene ring. It is known for its specificity in reacting with thiol groups present in proteins and other biomolecules, making it a valuable reagent in bioconjugation and chemical crosslinking reactions. The HCl salt form of 3-N-Maleimidobenzohydrazide-HCl is a stable solid that is water-soluble, which facilitates its use in various applications. Its capacity to form stable linkages with thiol-containing molecules positions it as a significant tool in chemical biology and biochemistry, particularly for studying and manipulating protein structure and function.

223528-57-2

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223528-57-2 Usage

Uses

Used in Bioconjugation:
3-N-Maleimidobenzohydrazide-HCl is used as a bioconjugation agent for selectively linking biomolecules, such as proteins, with other molecules or surfaces. Its reactivity with thiol groups allows for the formation of stable covalent bonds, which is crucial for creating stable and functional bioconjugates.
Used in Chemical Crosslinking:
In the field of chemical crosslinking, 3-N-Maleimidobenzohydrazide-HCl serves as a crosslinking agent to connect proteins or other biomolecules. This is particularly useful for studying protein-protein interactions, structural organization, and the dynamics of macromolecular complexes.
Used in Drug Development:
3-N-Maleimidobenzohydrazide-HCl is utilized in the development of drugs that target proteins with thiol groups. By forming covalent bonds with these groups, it can enhance the specificity and efficacy of therapeutic agents.
Used in Research and Diagnostics:
3-N-Maleimidobenzohydrazide-HCl is also used in research and diagnostic applications where the modification of proteins with maleimide or hydrazide functionalities is required. It aids in the investigation of protein function, structure, and interactions, as well as in the development of diagnostic tools that rely on the specific binding properties of these functional groups.
Used in Chemical Biology:
3-N-Maleimidobenzohydrazide-HCl is employed in chemical biology for the study of protein function and the development of protein-based therapeutics. Its ability to form stable linkages with thiol-containing molecules makes it an essential component in the toolkit of chemical biologists working on protein engineering and the design of novel bioactive compounds.

Check Digit Verification of cas no

The CAS Registry Mumber 223528-57-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,2,3,5,2 and 8 respectively; the second part has 2 digits, 5 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 223528-57:
(8*2)+(7*2)+(6*3)+(5*5)+(4*2)+(3*8)+(2*5)+(1*7)=122
122 % 10 = 2
So 223528-57-2 is a valid CAS Registry Number.

223528-57-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 3-(2,5-dioxopyrrol-1-yl)benzohydrazide,hydrochloride

1.2 Other means of identification

Product number -
Other names 3-N-maleimidobenzohydrazide-hydrochloride

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:223528-57-2 SDS

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