223553-31-9Relevant academic research and scientific papers
Photodecarboxylative benzylations of phthalimide in pH 7 buffer: A simple access to 3-arylmethyleneisoindolin-1-ones
Belluau, Vincent,Noeureuil, Pierre,Ratzke, Elfrun,Skvortsov, Aleksei,Gallagher, Sonia,Motti, Cherri Ann,Oelgem?ller, Michael
experimental part, p. 4738 - 4741 (2010/10/02)
Photoadditions of phenylacetates to phthalimide in pH 7 buffer solution give the corresponding benzylated-hydroxyphthalimidines in moderate to high yields of up to 94%. In a micro-structured reactor, higher conversions and purities are achieved. With branched phenylacetates, photoaddition affords diastereoisomeric mixtures with low to moderate de values. Subsequent acid-catalyzed dehydration furnishes the corresponding 3- arylmethyleneisoindolin-1-ones in good to excellent yields and with high E-selectivities. Irradiation of the parent 3-phenylmethyleneisoindolin-1-one under oxidative conditions only leads to cis/trans-isomerization.
Fused pyridine derivatives
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Example 221, (2010/01/30)
The present provides a condensed pyridine compound (I) represented by the following formula: (wherein, R2represents ring A represents benzene ring, pyridine ring, thiophene ring or furan ring; and B represents its pharmaceutically acceptable salt or hydrates thereof, which is a clinically useful medicament having a serotonin antagonism, in particular, that for treating, ameliorating or preventing spastic paralysis or central muscle relaxants for ameliorating myotonia.
SET photochemistry of phthalimide anion and its reactivity with hydrogen donors
Sánchez-Sánchez, Cristobal,Pérez-Inestrosa, Ezequiel,García-Segura, Rafael,Suau, Rafael
, p. 7267 - 7274 (2007/10/03)
The investigation of the photochemistry of phthalimide anion has uncovered its exceptional reactivity with hydrogen donors such as alcohols, toluene, ethers and amines. Photoreactions can be conducted to high conversions and photoadducts are formed in high yield and with predictable regioselectivity. Exploratory studies have revealed that SET from the excited phthalimide anion to phthalimide is a thermodinamically favourable step that produces the electrophilic phthalimidyl radical and is the key step of the process.
Prostanoids and related compounds. VI. Synthesis of isoindolinone derivatives possessing inhibitory activity for thromboxane A2 analog (U- 46619)-induced vasoconstriction
Kato,Takemoto,Achiwa
, p. 2003 - 2006 (2007/10/02)
We have synthesized 3-(o, m or p-substituted benzylidene)isoindolinone and 3-(2-o, m or p-substituted phenylethylidene)isoindolinone, which possess inhibitory activity for thromboxane A2 analog (U-46619)-induced vasoconstriction.
