223562-51-4

Basic information

• Product Name: Pyridine, 3-(1-propynyl)- (9CI)
• Synonyms: Pyridine, 3-(1-propynyl)- (9CI)
• CAS NO: 223562-51-4
• Molecular Formula: C8H7N
• Molecular Weight: 117.14788
• Product Categories: PYRIDINE
• Mol File: 223562-51-4.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Pyridine, 3-(1-propynyl)- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Pyridine, 3-(1-propynyl)- (9CI)(223562-51-4)
• EPA Substance Registry System: Pyridine, 3-(1-propynyl)- (9CI)(223562-51-4)

Safety Data

• Hazardous Substances Data: 223562-51-4(Hazardous Substances Data)

Upstream product

• 626-55-1 3-Bromopyridine 
• 590-93-2 2-Butynoic acid 
• 74-99-7 prop-1-yne 

Downstream Products

• 80673-00-3 3-[(trimethylsilyl)ethynyl]pyridine 
• 219480-93-0 3-(hex-1-yn-1-yl)pyridine 

Relevant articles and documents

COLLAGEN 1 TRANSLATION INHIBITORS AND METHODS OF USE THEREOF

The present invention relates to novel Collagen 1 translation inhibitors, composition and methods of preparation thereof, and uses thereof for treating Fibrosis including lung, liver, kidney, cardiac and dermal fibrosis, IPF, wound healing, scarring and G

Transformation of Carbonyl Compounds into Homologous Alkynes under Neutral Conditions: Fragmentation of Tetrazoles Derived from Cyanophosphates

Cyanophosphates (CPs) can be easily prepared from either ketones or aldehydes, and their reaction with NaN3-Et3N·HCl results in the formation of azidotetrazoles. Under microwave irradiation, successive fragmentation of the azidotetrazoles generates alkylidene carbenes that undergo [1,2]-rearrangement and are transformed into homologous alkynes. Treatment of ketone-derived CPs with TMSN3 and Bu2SnO as catalyst in toluene at reflux directly yields the corresponding internal alkynes, whereas the reaction of aldehyde-derived CPs with NaN3-Et3N·HCl in THF at reflux or TMSN3-Bu2SnO (cat.) in toluene at reflux provides homologous terminal alkynes in good yields. These reactions take place under neutral conditions and can be successfully extended to obtain alkynes that are not usually accessible from the corresponding carbonyl compounds by the Ohira-Bestmann or Shioiri procedures, which require basic conditions.