223591-08-0

Upstream product

• 223590-98-5 (1S,3RS,4R,7S)-7-benzyloxy-1-benzyloxymethyl-3-methoxy-2,5-dioxabicyclo[2.2.1]heptane 
• 219854-34-9 3-O-benzyl-4-[(benzyloxy)methyl]-1,2-O-(1-methylethylidene)-5-O-(methylsulfonyl)-β-L-lyxofuranose 
• 219854-35-0 methyl 3,5-di-O-benzyl-4-C-methylsulfonyloxymethyl-α,β-D-ribofuranoside 
• 153186-10-8 ((3aR,5R,6S,6aR)-6-(benzyloxy)-5-((benzyloxy)methyl)-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxol-5-yl)methanol 
• 223590-99-6 (2S,3S,4S)-3-benzyloxy-4-benzyloxymethyl-2-hydroxymethyl-4-hydroxytetrahydrofuran 
• 223591-06-8 (2S,3S,4S)-3-benzyloxy-4-benzyloxymethyl-2-(p-toluenesulfonyl)oxymethyl-4-hydroxytetrahydrofuran 
• 223591-10-4 (2R,3S,4S)-3-benzyloxy-4-benzyloxymethyl-2-formyl-4-hydroxytetrahydrofuran 

Downstream Products

• 223591-04-6 (1R,4S,7S)-1-(4,4'-dimethoxytrityl)oxymethyl-7-hydroxy-2,5-dioxabicyclo[2.2.1]heptane 

Relevant academic research and scientific papers

Synthesis of abasic locked nucleic acid and two seco-LNA derivatives and evaluation of their hybridization properties compared with their more flexible DNA counterparts

To investigate the structural basis of the unique hybridization properties of LNA (locked nucleic acid)1 three novel LNA derivatives with modified carbohydrate parts were synthesized and evaluated with respect to duplex stabilities. The abasic LNA monomer2 (X(L), Figure 1) with the rigid carbohydrate moiety of LNA but no nucleobase attached showed no enhanced duplex stabilities compared to its more flexible abasic DNA counterpart (X, Figure 1). These results suggest that the exceptional hybridization properties of LNA primarily originate from improved intrastrand nucleobase stacking and not backbone preorganization. Two monocyclic seco-LNA derivatives, obtained by cleavage of the C1' - O4' bond of an LNA monomer or complete removal of the O4' - furanose oxygen atom (Z(L) and dZ(L), respectively, Figure 1), were compared to their acyclic DNA counterpart3 (Z, Figure 1). Even though they are more constrained than Z, the seco-LNA derivatives Z(L) and dZ(L) destabilize duplex formation even more than the flexible seco-DNA monomer Z.

Triplex-forming enhancement with high sequence selectivity by single 2'-O,4'-C-methylene bridged nucleic acid (2',4'-BNA) modification

Triplex-forming ability of the oligonucleotides containing one 2'-O,4'-C-methyleneribonucleic acid (2',4'-BNA) unit was investigated by measurement of the melting temperature (T(m)), and the 2',4'-BNA modification promoted the marked triplex stabilization

Investigation of restricted backbone conformations as an explanation for the exceptional thermal stabilities of duplexes involving LNA (Locked Nucleic Acid): Synthesis and evaluation of abasic LNA

In order to investigate the structural basis of the unique hybridization properties of LNA (Locked Nucleic Acid), an abasic LNA monomer (a 1-deoxy-2-O,4-C-methylene-D-ribofuranose derivative) was synthesized and evaluated with respect to influence on dupl