223595-15-1

Usage

Uses

Used in Pharmaceutical Industry:
1-Propanone, 1-[(1R)-5-bromo-1,3-dihydro-1-methyl-2H-isoindol-2-yl]-2,2-dimethylis used as a potential treatment for neurodegenerative diseases, particularly Alzheimer's disease. It targets protein-protein interactions that play a crucial role in the progression of these conditions, offering a novel approach to managing and potentially treating such diseases.
Used in Research and Development:
In the field of research and development, 1-Propanone, 1-[(1R)-5-bromo-1,3-dihydro-1-methyl-2H-isoindol-2-yl]-2,2-dimethylserves as a valuable tool for studying the underlying mechanisms of neurodegenerative diseases. Its selectivity and potency in inhibiting specific protein-protein interactions make it an important compound for preclinical studies and the development of new therapeutic strategies.

Downstream Products

• 194805-14-6 (+)-(R)-5-bromo-1-methyl-2-(triphenylmethyl)isoindoline 

Relevant academic research and scientific papers

Processes for producing 7-isoindolinequinolonecarboxylic derivatives and intermediates therefor, salts of 7-isoindolinequinolonecarboxylic acids, hydrates thereof, and composition containing the same as active ingredient

This invention relates to processes for producing a 7-isoindoline-quinolonecarboxylic acid derivative represented by the general formula [1] which is useful as an antibacterial agent, and an intermediate thereof: wherein R1represents a hydrogen atom or a carboxyl-protecting group; R2represents a substituted or unsubstituted alkyl, alkenyl, cycloalkyl, aryl or heterocyclic group; R3represents at least one group selected from hydrogen atom, halogen atoms, substituted or unsubstituted alkyl, alkenyl, cycloalkyl, aryl, alkoxy or alkylthio groups, nitro group, cyano group, acyl groups, protected or unprotected hydroxyl groups and protected or unprotected or substituted or unsubstituted amino groups; R4represents at least one group selected from hydrogen atom, halogen atoms, substituted or unsubstituted alkyl, alkenyl, cycloalkyl, aralkyl, aryl, alkoxy or alkylthio groups, protected or unprotected hydroxyl or imino groups, protected or unprotected or substituted or unsubstituted amino groups, alkylidene groups, oxo group and groups each forming a cycloalkane group together with the carbon atom to which R4bonds; R5represents a hydrogen atom, an amino-protecting group, a substituted or unsubstituted alkyl, cycloalkyl, alkylsulfonyl, arylsulfonyl, acyl or aryl group; R6represents a hydrogen atom, a halogen atom, a substituted or unsubstituted alkyl, alkoxy or alkylthio group, a protected or unprotected hydroxyl or amino group or a nitro group; and A represents CH or C—R7in which R7represents a halogen atom, a substituted or unsubstituted alkyl, alkoxy or alkylthio group or a protected or unprotected hydroxyl group, and to a salt of a 7-isoindoline-quinolonecarboxylic acid represented by the general formula [1], a hydrate thereof and a composition comprising them as an active ingredient.