223646-21-7

Usage

Uses

Used in Pharmaceutical Research:
2,3-Dihydro-2-oxo-1H-pyrrolo[2,3-b]pyridine-5-carboxylic acid ethyl ester is used as a key intermediate in the synthesis of pharmaceutical compounds for various therapeutic applications. Its unique structure and potential biological activities make it a valuable candidate for the development of new drugs.
Used in Organic Synthesis:
In the field of organic synthesis, 2,3-Dihydro-2-oxo-1H-pyrrolo[2,3-b]pyridine-5-carboxylic acid ethyl ester serves as a building block for the construction of more complex organic molecules. Its presence in these molecules can impart specific properties and functionalities, making it a useful component in the synthesis of various organic compounds.
Used as a Reagent in Chemical Reactions:
2,3-Dihydro-2-oxo-1H-pyrrolo[2,3-b]pyridine-5-carboxylic acid ethyl ester is used as a reagent in chemical reactions to introduce the pyridine ring into various organic compounds. The pyridine ring is an important structural element in many organic and pharmaceutical compounds, and this ester can facilitate its incorporation into target molecules, enhancing their properties and potential applications.

Upstream product

• 201230-82-2 carbon monoxide 
• 3375-31-3 palladium diacetate 
• 183208-34-6 5-bromo-1,3-dihydro-2H-pyrrolo[2,3-b]pyridin-2-one 
• 64-17-5 ethanol 

Relevant academic research and scientific papers

Oxindole derivatives

The present invention is related to oxindole derivatives, compositions containing the same, and methods of use and manufacture of the same. Such compounds generally are useful pharmacologically as agents in those disease states alleviated by the alteration of mitogen activated signaling pathways in general, and in particular in the inhibition or antagonism of protein kinases, which pathologically involve aberrant cellular proliferation. Such disease states include tumor growth, restenosis, atherosclerosis, pain and thrombosis. In particular, the present invention relates to a series of substituted oxindole compounds, which exhibit Trk family protein tyrosine kinase inhibition, and which are useful in cancer therapy and chronic pain indications.

Substituted aza-oxindole derivatives

Substituted aza-oxindole derivatives useful as cyclin dependent kinase 11 inhibitors, for preventing/reducing the severity of epithelial cytotoxicity side-effects (e.g., alopecia, plantar-palmar syndrome, mucositis) induced by chemoptherapy and/or radiati

3-(anilinomethylene) oxindoles

The present invention relates generally to novel amine substituted oxindole compounds and compositions. Such compounds and compositions have utility as pharmacological agents in treating diseases or conditions alleviated by the inhibition or antagonism of

Synthesis of 5-Substituted 7-Azaoxindoles via Palladium-Catalyzed Reactions

A synthesis of 5-substituted 1,3-dihydro-2H-pyrrolo[2,3-b]pyridin-2-ones (5-substituted 7-azaoxindoles) via palladium-catalyzed Suzuki coupling, Stille coupling, and carbonylation reactions is described.