223671-17-8

Basic information

• Product Name: 5-Bromo-2-isoquinolin-2-one
• Synonyms: 5-Bromo-2-isoquinolin-2-one;5-bromo-2-oxido-isoquinolin-2-ium
• CAS NO: 223671-17-8
• Molecular Formula: C9H6BrNO
• Molecular Weight: 224.05404
• Mol File: 223671-17-8.mol
• Article Data: 22

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 5-Bromo-2-isoquinolin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Bromo-2-isoquinolin-2-one(223671-17-8)
• EPA Substance Registry System: 5-Bromo-2-isoquinolin-2-one(223671-17-8)

Safety Data

• Hazardous Substances Data: 223671-17-8(Hazardous Substances Data)

Upstream product

• 3132-99-8 m-bromobenzoic aldehyde 
• 34784-04-8 5-bromoisoquinoline 

Downstream Products

• 190777-77-6 5-bromo-1,2-dihydroisoquinolin-1-one 
• 1612222-98-6 methyl 2-(5-bromoisoquinolin-1-yl)acetate 

Relevant articles and documents

Cu(II)-Catalyzed Construction of Heterobiaryls using 1-Diazonaphthoquinones: A General Strategy for the Synthesis of QUINOX and Related P,N Ligands

An efficient and straightforward method was developed for the synthesis of heterobiaryls using easily available N-oxides and diazonaphthoquinones under cheap Cu(II) catalysis. The developed method offered QUINOX and related congeners in a simple manner. A wide scope of important heterobiaryls was achieved with high site selectivity. The synthesized naphthols were transformed into the privileged related P,N ligands. Suitable resolution methods can directly afford the corresponding axially chiral heterobiaryls.

Efficient visible light mediated synthesis of quinolin-2(1H)-ones from quinolineN-oxides

Quinolin-2(1H)-ones are one of the important classes of compounds due to their prevalence in natural products and in pharmacologically useful compounds. Here we present an unconventional and hitherto unknown photocatalytic approach to their synthesis from easily available quinoline-N-oxides. This reagent free highly atom economical photocatalytic method, with low catalyst loading, high yield and no undesirable by-product, provides an efficient greener alternative to all conventional synthesis reported to date. The robustness of the methodology has been successfully demonstrated with easy scaling up to the gram scale.

Light-induced [2 + 2] cycloadditions for the construction of cyclobutane-fused pyridinyl sulfonyl fluorides

Cyclobutanes are an important class of motifs present in a wide range of natural products and other biologically significant molecules. A photocatalytic [2 + 2] cycloaddition between pyridones or isoquinolones and ethenesulfonyl fluoride was achieved, providing a portal to a class of unique cyclobutane-fused pyridinyl sulfonyl fluorides with quaternary rigid rings (30 examples). Further applications of these novel sulfonyl fluoride molecules in SuFEx click chemistry were also accomplished, providing the corresponding sulfonates and sulphonamides with reasonable yields.