223674-65-5

Basic information

• Product Name: 3-chloro-2-(p-tolyl)thiophene
• Synonyms: 3-chloro-2-(p-tolyl)thiophene
• CAS NO: 223674-65-5
• Molecular Weight: 208.711
• Mol File: 223674-65-5.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 3-chloro-2-(p-tolyl)thiophene(CAS DataBase Reference)
• NIST Chemistry Reference: 3-chloro-2-(p-tolyl)thiophene(223674-65-5)
• EPA Substance Registry System: 3-chloro-2-(p-tolyl)thiophene(223674-65-5)

Safety Data

• Hazardous Substances Data: 223674-65-5(Hazardous Substances Data)

Upstream product

• 17249-80-8 3-chlorothiophene 
• 624-31-7 4-tolyl iodide 

Relevant articles and documents

Ag(I)-C-H Activation Enables Near-Room-Temperature Direct α-Arylation of Benzo[ b]thiophenes

The first example of near-room-temperature α-arylation of benzo[b]thiophenes is reported. The discovery rests on the observation of a switch in α-/β-regioselectivity at different loadings of Pd2(dba)3·CHCl3 in the coupling between benzo[b]thiophene and 4-iodotoluene. We show that this unprecedented regioselectivity switch is driven by a Ag(I)-mediated C-H activation at the α-C-H position, which becomes the dominant mode of reactivity at low concentrations of Pd. Competition experiments, kinetic studies, KIE, and D/H scrambling experiments have been carried out supporting this mechanism.

Room-temperature direct arylation of polyfluorinated arenes under biphasic conditions

Figure presented New biphasic conditions for the palladium-catalyzed direct arylation of electron-poor fluorinated arenes have been developed. Taking advantage of biphasic chemistry, the use of an immiscible mixture of water and an organic solvent allows