223685-14-1

Basic information

• Product Name: 4-<<(3-Chlorophenyl)sulfanyl>methyl>-1-methylpiperidine
• CAS NO: 223685-14-1
• Molecular Weight: 255.812
• Mol File: 223685-14-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-<<(3-Chlorophenyl)sulfanyl>methyl>-1-methylpiperidine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-<<(3-Chlorophenyl)sulfanyl>methyl>-1-methylpiperidine(223685-14-1)
• EPA Substance Registry System: 4-<<(3-Chlorophenyl)sulfanyl>methyl>-1-methylpiperidine(223685-14-1)

Safety Data

• Hazardous Substances Data: 223685-14-1(Hazardous Substances Data)

Upstream product

• 52694-51-6 4-(chloromethyl)-1-methylpiperidine 
• 2037-31-2 3-chlorophenylthiol 

Relevant articles and documents

Molecular modification of anpirtoline, a non-opioid centrally acting analgesic

Molecular modification of anpirtoline (2a) is described. Several methods of preparation of 4-[(3-chlorophenyl)sulfanyl]-1-methylpiperidine (3a) and its demethylation led to the deazaanpirtoline (3c). Nucleophilic substitution of piperidine-4-thiole with 2-chloro-4-nitropyridine, 2,4-dichloro-6-methylpyridine, and 3,6-dichloropyridazine led to 2-chloro-4-(piperidin-4-ylsulfanyl)pyridine (6), 4-chloro-6-methyl-2-(piperidin-4-ylsulfanyl)pyridine (7), and 3-chloro-6-(piperidin-4-ylsulfanyl)pyridazine (8), respectively. 2-Chloro-6-(pyridin-4-ylsulfanyl)-pyridine (10) and 4-[(2-chloropyridin-6-yl)sulfanyl]quinoline (11) were obtained from sodium 2-chloropyridine-6-thiolate. Homoanpirtoline analogs with methylene group inserted between the pyridine moiety and the sulfur atom (compound 12b) as well as between the sulfur atom and the piperidine ring (compound 13b) were also prepared.