2237-14-1

Basic information

• Product Name: 1,4-BENZOQUINONE-D4
• Synonyms: QUINONE (D4);1,4-BENZOQUINONE-D4;1,4-BENZOQUINONE-D4, 98 ATOM % D;2,5-Cyclohexadiene-1,4-dione-2,3,5,6-d4;p-benzoquinone-d4
• CAS NO: 2237-14-1
• Molecular Formula: C₆H₄O₂
• Molecular Weight: 112.12
• Mol File: 2237-14-1.mol
• Article Data: 5

Chemical Properties

• Melting Point: 113-115 °C(lit.)
• Boiling Point: 174 °C at 760 mmHg
• Flash Point: 77℃
• Appearance: /
• Density: 1.303 g/cm³
• Vapor Pressure: 1.23mmHg at 25°C
• Refractive Index: 1.543
• CAS DataBase Reference: 1,4-BENZOQUINONE-D4(CAS DataBase Reference)
• NIST Chemistry Reference: 1,4-BENZOQUINONE-D4(2237-14-1)
• EPA Substance Registry System: 1,4-BENZOQUINONE-D4(2237-14-1)

Safety Data

• Hazard Codes: T
• Statements: 23/24/25
• Safety Statements: 26-36/37/39-45
• RIDADR: UN 2587 6.1/PG 2
• WGK Germany: 3
• Hazardous Substances Data: 2237-14-1(Hazardous Substances Data)

Usage

Description

1,4-BENZOQUINONE-D4, also known as p-benzoquinone, is a stable, heavy isotope-labeled derivative of the organic compound benzoquinone. It is commonly used in research and testing as a stable isotope-labeled internal standard for the determination and quantification of benzoquinone in various samples.
Used in Environmental Analysis:
1,4-BENZOQUINONE-D4 is used as an internal standard for the accurate and precise analysis of benzoquinone levels in environmental samples, such as air, water, and soil.
Used in Forensic Toxicology:
1,4-BENZOQUINONE-D4 is used as an internal standard for the identification and quantification of benzoquinone in biological samples, such as blood, urine, and tissue, in forensic investigations.
Used in Biochemical Studies:
1,4-BENZOQUINONE-D4 is used as an internal standard for the study of benzoquinone and its related compounds in biochemical research, including their roles in metabolic pathways and enzyme reactions.
Used in Analytical Testing:
1,4-BENZOQUINONE-D4 is used as an internal standard for the accurate and precise quantification of benzoquinone in various samples, ensuring reliable results in analytical testing.

InChI:InChI=1/C6H4O2/c7-5-1-2-6(8)4-3-5/h1-4H/i1D,2D,3D,4D

Upstream product

• 87-87-6 2,3,5,6-tetrachlorobenzene-1,4-diol 
• 25294-85-3 <2H4>Hydrochinone 
• 123-31-9 hydroquinone 
• 71589-26-9 perdeuteriohydroquinone 

Downstream Products

• 393-40-8 2-(trifluoromethyl)cyclohexa-2,5-diene-1,4-dione 

Relevant articles and documents

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Development of isotope-enriched phosphatidylinositol-4- And 5-phosphate cellular mass spectrometry probes

Synthetic phosphatidylinositol phosphate (PtdInsPn) derivatives play a pivotal role in broadening our understanding of PtdInsPnmetabolism. However, the development of such tools is reliant on efficient enantioselective and regioselective synthetic strategies. Here we report the development of a divergent synthetic route applicable to the synthesis of deuterated PtdIns4Pand PtdIns5Pderivatives. The synthetic strategy developed involves a key enzymatic desymmetrisation step using Lipozyme TL-IM. In addition, we optimised the large-scale synthesis of deuteratedmyo-inositol, allowing for the preparation of a series of saturated and unsaturated deuterated PtdIns4Pand PtdIns5Pderivatives. Experiments in MCF7 cells demonstrated that these deuterated probes enable quantification of the corresponding endogenous phospholipids in a cellular setting. Overall, these deuterated probes will be powerful tools to help improve our understanding of the role played by PtdInsPnin physiology and disease.

Reductive Dehalogenation and Ring Saturation of Halogenated Hydroquinones, Catechol, and Resorcinol with Raney Alloys in NaOD-D2O Solution Leading to Hydroquinones, 1,4-Cyclohexanediol and 1,3-Cyclohexanedione Labeled with Deuterium

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