2237-14-1Relevant articles and documents
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Ogata et al.
, p. 2715,2720 (1969)
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Development of isotope-enriched phosphatidylinositol-4- And 5-phosphate cellular mass spectrometry probes
Joffrin, Amélie M.,Saunders, Alex M.,Barneda, David,Flemington, Vikki,Thompson, Amber L.,Sanganee, Hitesh J.,Conway, Stuart J.
, p. 2549 - 2557 (2021/03/01)
Synthetic phosphatidylinositol phosphate (PtdInsPn) derivatives play a pivotal role in broadening our understanding of PtdInsPnmetabolism. However, the development of such tools is reliant on efficient enantioselective and regioselective synthetic strategies. Here we report the development of a divergent synthetic route applicable to the synthesis of deuterated PtdIns4Pand PtdIns5Pderivatives. The synthetic strategy developed involves a key enzymatic desymmetrisation step using Lipozyme TL-IM. In addition, we optimised the large-scale synthesis of deuteratedmyo-inositol, allowing for the preparation of a series of saturated and unsaturated deuterated PtdIns4Pand PtdIns5Pderivatives. Experiments in MCF7 cells demonstrated that these deuterated probes enable quantification of the corresponding endogenous phospholipids in a cellular setting. Overall, these deuterated probes will be powerful tools to help improve our understanding of the role played by PtdInsPnin physiology and disease.
Reductive Dehalogenation and Ring Saturation of Halogenated Hydroquinones, Catechol, and Resorcinol with Raney Alloys in NaOD-D2O Solution Leading to Hydroquinones, 1,4-Cyclohexanediol and 1,3-Cyclohexanedione Labeled with Deuterium
Tsuzuki, Hirohisa,Iyama, Hironobu,Tsukinoki, Takehito,Mukumoto, Mamoru,Yonemitsu, Tadashi,et al.
, p. 1701 - 1716 (2007/10/02)
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