22371-32-0

Usage

Uses

Used in Pharmaceutical and Agrochemical Production:
HEPTANOICACIDHYDRAZIDE is used as an intermediate in the synthesis of various pharmaceuticals and agrochemicals for its ability to facilitate the creation of complex organic compounds.
Used in Corrosion Inhibition:
HEPTANOICACIDHYDRAZIDE is used as a corrosion inhibitor for its potential to protect materials from degradation, extending their lifespan and improving their performance in various industrial applications.
Used in Antiviral and Antibacterial Applications:
HEPTANOICACIDHYDRAZIDE is used as an antiviral and antibacterial agent due to its studied properties that may inhibit the growth of viruses and bacteria, offering potential benefits in healthcare and sanitation.
Used as a Flame Retardant:
HEPTANOICACIDHYDRAZIDE is used as a flame retardant for its potential to slow down or prevent the spread of flames, making it valuable in industries where fire safety is a critical concern.
Used in Controlled Release of Active Ingredients in Polymeric Materials:
HEPTANOICACIDHYDRAZIDE is used as an agent for controlling the release of active ingredients in polymeric materials, allowing for a more efficient and targeted delivery of substances in various applications, such as agriculture, pharmaceuticals, and personal care products.

InChI:InChI=1/C7H16N2O/c1-2-3-4-5-6-7(10)9-8/h2-6,8H2,1H3,(H,9,10)

Upstream product

• 106-73-0 methyl heptanoate 
• 2528-61-2 Heptanoic acid chloride 
• 106-30-9 ethyl heptanoate 
• 111-14-8 oenanthic acid 
• 3378-34-5 N,N'-diheptyldiazene N,N'-dioxide 
• 373-49-9 cis-9-hexadecenoic acid 

Downstream Products

• 77477-56-6 2-Hexyl-5-<4-pentyloxy-phenyl>-1,3,4-thiadiazol 
• 77477-57-7 2-Hexyl-5-<4-hexyloxy-phenyl>-1,3,4-thiadiazol 
• 77477-58-8 2-Hexyl-5-<4-heptyloxy-phenyl>-1,3,4-thiadiazol 
• 77477-59-9 2-Hexyl-5-<4-octyloxy-phenyl>-1,3,4-thiadiazol 

Relevant academic research and scientific papers

Design, Synthesis, and Study of the Insecticidal Activity of Novel Steroidal 1,3,4-Oxadiazoles

A series of novel steroidal derivatives with a substituted 1,3,4-oxadiazole structure was designed and synthesized, and the target compounds were evaluated for their insecticidal activity against five aphid species. Most of the tested compounds exhibited potent insecticidal activity against Eriosoma lanigerum (Hausmann), Myzus persicae, and Aphis citricola. Compounds 20g and 24g displayed the highest activity against E. lanigerum, showing LC50 values of 27.6 and 30.4 μg/mL, respectively. Ultrastructural changes in the midgut cells of E. lanigerum were detected by transmission electron microscopy, indicating that these steroidal oxazole derivatives might exert their insecticidal activity by destroying the mitochondria and nuclear membranes in insect midgut cells. Furthermore, a field trial showed that compound 20g exhibited effects similar to those of the positive controls chlorpyrifos and thiamethoxam against E. lanigerum, reaching a control rate of 89.5% at a dose of 200 μg/mL after 21 days. We also investigated the hydrolysis and metabolism of the target compounds in E. lanigerum by assaying the activities of three insecticide-detoxifying enzymes. Compound 20g at 50 μg/mL exhibited inhibitory action on carboxylesterase similar to the known inhibitor triphenyl phosphate. The above results demonstrate the potential of these steroidal oxazole derivatives to be developed as novel pesticides.

FLOW CHEMISTRY SYNTHESIS OF ISOCYANATES

The disclosure provides, inter alia, safe and environmentally-friendly methods, such as flow chemistry, to synthesize isocyanates, such as methylene diphenyl diisocyanate, toluene diisocyanate, hexamethylene diisocyanate, isophorone diisocyanate, and tetramethylxylene diisocyanate.

Natural product inspired optimization of a selective TRPV6 calcium channel inhibitor

Transient receptor potential vanilloid 6 (TRPV6) is a calcium channel implicated in multifactorial diseases and overexpressed in numerous cancers. We recently reported the phenyl-cyclohexyl-piperazine cis-22a as the first submicromolar TRPV6 inhibitor. This inhibitor showed a seven-fold selectivity against the closely related calcium channel TRPV5 and no activity on store-operated calcium channels (SOC), but very significant off-target effects and low microsomal stability. Here, we surveyed analogues incorporating structural features of the natural product capsaicin and identified 3OG, a new oxygenated analog with similar potency against TRPV6 (IC50 = 0.082 ± 0.004 μM) and ion channel selectivity, but with high microsomal stability and very low off-target effects. This natural product-inspired inhibitor does not exhibit any non-specific toxicity effects on various cell lines and is proposed as a new tool compound to test pharmacological inhibition of TRPV6 mediated calcium flux in disease models.

Study on DDQ-promoted synthesis of 2, 5-disubstituted 1, 3, 4-oxadiazoles from acid hydrazides and aldehydes

A facile stepwise synthesis of 2, 5-disubstituted 1, 3, 4-oxadiazoles proceeding via oxidative cyclization of N-acylhydrazones is reported. The reaction is efficiently promoted by 2, 3-dichloro-5, 6-dicyano-1, 4- benzoquinone (DDQ) to afford the desired products mostly in high yields and in relatively short times. The final 1, 3, 4-oxadiazole derivatives are also synthesized directly from acid hydrazides and aldehydes in a one-pot procedure. The substrate scope and limitations of the reported transformation are discussed in detail.

Parameters of synthesis of hydrazides and 1,2-diacylhydrazines by thermal decomposition of hydrazine salts of aliphatic carboxylic acids

The reaction parameters were refined for synthesis of hydrazides and 1,2-diacylhydrazines by thermal decomposition of salts of aliphatic carboxylic acids of the general formulas RCOOH · N2H4 · H2O and 2RCOOH-N2H4-H2O (R = C2H5-C8H17). Derivatograms for series of compounds were obtained. The effect of hydrazine hydrate excess, temperature, reaction duration, and crystallization conditions on the yield and quality of hydrazides of C7-C9 carboxylic acids was studied.