22371-32-0

Basic information

• Product Name: HEPTANOICACIDHYDRAZIDE
• Synonyms: enanthohydrazide;heptanehydrazide
• CAS NO: 22371-32-0
• Molecular Formula: C₇H₁₆N₂O
• Molecular Weight: 144.22
• Mol File: 22371-32-0.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 287.3°Cat760mmHg
• Flash Point: 127.6°C
• Appearance: /
• Density: 0.938g/cm³
• Vapor Pressure: 0.0025mmHg at 25°C
• Refractive Index: 1.454
• CAS DataBase Reference: HEPTANOICACIDHYDRAZIDE(CAS DataBase Reference)
• NIST Chemistry Reference: HEPTANOICACIDHYDRAZIDE(22371-32-0)
• EPA Substance Registry System: HEPTANOICACIDHYDRAZIDE(22371-32-0)

Safety Data

• Hazardous Substances Data: 22371-32-0(Hazardous Substances Data)

Usage

General Description

Heptanoic acid hydrazide, also known as n-heptyl hydrazinecarboxylate, is a chemical compound with the molecular formula C7H16N2O. It is a hydrazide derivative of heptanoic acid, and is commonly used as an intermediate in the production of pharmaceuticals, agrochemicals, and other organic compounds. Heptanoic acid hydrazide is a colorless, odorless solid that is soluble in water and organic solvents. It has been studied for its potential use as a corrosion inhibitor, and has also been investigated for its antiviral and antibacterial properties. Additionally, it has been shown to have potential as a flame retardant and as an agent for controlling the release of active ingredients in polymeric materials.

InChI:InChI=1/C7H16N2O/c1-2-3-4-5-6-7(10)9-8/h2-6,8H2,1H3,(H,9,10)

Upstream product

• 111-14-8 oenanthic acid 
• 106-30-9 ethyl heptanoate 
• 373-49-9 cis-9-hexadecenoic acid 
• 2528-61-2 Heptanoic acid chloride 
• 3378-34-5 N,N'-diheptyldiazene N,N'-dioxide 
• 106-73-0 methyl heptanoate 

Downstream Products

• 77477-59-9 2-Hexyl-5-<4-octyloxy-phenyl>-1,3,4-thiadiazol 
• 77477-58-8 2-Hexyl-5-<4-heptyloxy-phenyl>-1,3,4-thiadiazol 
• 77477-57-7 2-Hexyl-5-<4-hexyloxy-phenyl>-1,3,4-thiadiazol 
• 77477-56-6 2-Hexyl-5-<4-pentyloxy-phenyl>-1,3,4-thiadiazol 

Relevant articles and documents

FLOW CHEMISTRY SYNTHESIS OF ISOCYANATES

The disclosure provides, inter alia, safe and environmentally-friendly methods, such as flow chemistry, to synthesize isocyanates, such as methylene diphenyl diisocyanate, toluene diisocyanate, hexamethylene diisocyanate, isophorone diisocyanate, and tetramethylxylene diisocyanate.

Natural product inspired optimization of a selective TRPV6 calcium channel inhibitor

Transient receptor potential vanilloid 6 (TRPV6) is a calcium channel implicated in multifactorial diseases and overexpressed in numerous cancers. We recently reported the phenyl-cyclohexyl-piperazine cis-22a as the first submicromolar TRPV6 inhibitor. This inhibitor showed a seven-fold selectivity against the closely related calcium channel TRPV5 and no activity on store-operated calcium channels (SOC), but very significant off-target effects and low microsomal stability. Here, we surveyed analogues incorporating structural features of the natural product capsaicin and identified 3OG, a new oxygenated analog with similar potency against TRPV6 (IC50 = 0.082 ± 0.004 μM) and ion channel selectivity, but with high microsomal stability and very low off-target effects. This natural product-inspired inhibitor does not exhibit any non-specific toxicity effects on various cell lines and is proposed as a new tool compound to test pharmacological inhibition of TRPV6 mediated calcium flux in disease models.

Parameters of synthesis of hydrazides and 1,2-diacylhydrazines by thermal decomposition of hydrazine salts of aliphatic carboxylic acids

The reaction parameters were refined for synthesis of hydrazides and 1,2-diacylhydrazines by thermal decomposition of salts of aliphatic carboxylic acids of the general formulas RCOOH · N2H4 · H2O and 2RCOOH-N2H4-H2O (R = C2H5-C8H17). Derivatograms for series of compounds were obtained. The effect of hydrazine hydrate excess, temperature, reaction duration, and crystallization conditions on the yield and quality of hydrazides of C7-C9 carboxylic acids was studied.