223717-80-4Relevant academic research and scientific papers
Synthesis and characterisation of some new N-glycosides containing substituted pyridopyrimidinone, pyrimidopyridazinone, thiazolopyrimidinone and quinolizin-4-one moiety
Simunek, Petr,Svete, Jurij,Stanovnik, Branko
experimental part, p. 2477 - 2491 (2011/04/17)
A series of new N-glycosides (D-glucosides, D-mannosides, L-and D-arabinosides, D-xylosides and one D-galactoside) containing heterocyclic moiety have been prepared by reaction of the corresponding heterocyclic amines with pyranoses in boiling methanol. The structures of the prepared compounds have been studied by means of proton and carbon NMR spectroscopy. In the most cases the products existed in DMSO solution as the single anomers. The Japan Institute of Heterocyclic Chemistry.
The synthesis of methyl 2-(benzyloxycarbonyl)amino-3- dimethylaminopropenoate. The synthesis of trisubstituted pyrroles, 3-amino- 2H-pyran-2-ones, fused 2H-pyran-2-ones and 4H-pyridin-4-ones
Toplak, Renata,Svete, Jurij,Stanovnik, Branko,Golic Grdadolnik, Simona
, p. 225 - 235 (2007/10/03)
Methyl 2-(benzyloxycarbonyl)amino-3-dimethylaminopropenoate (2) was prepared from methyl N-(benzyloxycarbonyl)glycinate (1) and t- butoxybis(dimethylamino)methane, and used as a reagent for preparation of substituted 3-(benzyloxycarbonyl)amino-4H-quinolizin-4-ones 5 and 6, -2H- pyran-2-ones 17-19, -2H-1-benzopyran-2-ones 28-31, and -naphthopyrans 32-35, -2H-pyrano[3,2-c]pyridine-2,5-dione 46, -pyrano[4,3-b]pyran-2,5-dione 47, - pyrano[3,2-c]benzopyran-2,5-dione 48, -pyrano[2,3-c]pyrazol-6-ones 49 and 50, -pyrano[2,3-d]pyrimidin-7-ones 51 and 52 derivatives. In the reaction of 2 with 1,3-diketones trisubstituted pyrroles 14-16 were formed. Selective removal of benzyloxycarbonyl group was achieved by catalytic transfer hydrogenation with Pd/C in the presence of cyclohexene to afford free 3- amino compounds 7, 8, 20, 36-38 and 53-57 in yields better than 80%.
