223726-07-6Relevant articles and documents
Quinuclidine inhibitors of 2,3-oxidosqualene cyclase-lanosterol synthase: Optimization from lipid profiles
Brown, George R.,Hollinshead, David M.,Stokes, Elaine S. E.,Clarke, David S.,Eakin, M. Allan,Foubister, Alan J.,Glossop, Steven C.,Griffiths, David,Johnson, Michael C.,McTaggart, Fergus,Mirrlees, Donald J.,Smith, Graham J.,Wood, Robin
, p. 1306 - 1311 (2007/10/03)
Novel 3-substituted quinuclidine inhibitors of cholesterol biosynthesis are reported. Compounds were optimized against oxidosqualene cyclase- lanosterol synthase (OSC) inhibition in vivo, rather than by the conventional optimization of structure-activity