22374-56-7Relevant academic research and scientific papers
Discovery of a novel class of inhaled dual pharmacology muscarinic antagonist and β2 agonist (MABA) for the treatment of chronic obstructive pulmonary disease (COPD)
Rancati, Fabio,Linney, Ian D.,Rizzi, Andrea,Delcanale, Maurizio,Knight, Chris K.,Schmidt, Wolfgang,Pastore, Fiorella,Riccardi, Benedetta,Mileo, Valentina,Carnini, Chiara,Cesari, Nicola,Blackaby, Wesley P.,Patacchini, Riccardo,Carzaniga, Laura
, (2021)
The targeting of both the muscarinic and β-adrenergic pathways is a well validated therapeutic approach for the treatment of chronic obstructive pulmonary disease (COPD). In this communication we report our effort to incorporate two pharmacologies into a single chemical entity, whose characteristic must be suitable for a once daily inhaled administration. Contextually, we aimed at a locally acting therapy with limited systemic absorption to minimize side effects. Our lung-tailored design of bifunctional compounds that combine the muscarinic and β-adrenergic pharmacologies by the elaboration of the muscarinic inhibitor 7, successfully led to the potent, pharmacologically balanced muscarinic antagonist and β2 agonist (MABA) 13.
Synthesis of C37-Alkenones for Past Climate Reconstructions
Berton, Giacomo,Pizzini, Sarah,Fabris, Fabrizio,Bertolin, Tommaso,Pafumi, Eugenia,Ceccon, Leonardo,Daelemans, Jonas,Borsato, Giuseppe,Scarso, Alessandro,Piazza, Rossano,Ferretti, Patrizia
, p. 3542 - 3551 (2020/03/26)
The total syntheses of three C37 methyl-alkenones with different degrees of unsaturation and of their 13C-labelled analogues from commercially available starting materials are presented herein for the first time. These molecules are important to improve the reliability of the measurements and reconstructions of the sea surface temperature and salinity.
Synthesis of (R)-(+)-patulolide A
Bestmann,Kellermann,Pecher
, p. 149 - 152 (2007/10/02)
A new total synthesis of (R)-(+)-patulolide A [(11R,2E)-4-oxo-2-dodecen-11-olide] using the cyclization of hydroxy aldehydes with ketenylidenetriphenylphosphorane is described.
Enantioselective Total Synthesis of Harmonine, a Defence Alkaloid of Ladybugs (Coleoptera: Coccinellidae)
Enders, Dieter,Bartzen, Dominika
, p. 569 - 574 (2007/10/02)
An efficient and highly enantioselective (ee > 97percent) total synthesis of the ladybug defence alkaloid (17R,9Z)-1,17-diaminooctadec-9-ene in good overall yield is described.As the key step for the generation of the stereogenic center, asymmetric C-C bond formation by nucleophilic addition of methyllithium to an aldehyde SAMP hydrazone is used. Key Words: (17R,9Z)-1,17-Diaminooctadec-9-ene / Harmonine / Ladybug / SAMP hydrazone
