223753-63-7

Basic information

• Product Name: Boc-Val-ψ-(CH2-NH)-Ala-Ala-pNA
• CAS NO: 223753-63-7
• Molecular Weight: 465.55
• Mol File: 223753-63-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Boc-Val-ψ-(CH2-NH)-Ala-Ala-pNA(CAS DataBase Reference)
• NIST Chemistry Reference: Boc-Val-ψ-(CH2-NH)-Ala-Ala-pNA(223753-63-7)
• EPA Substance Registry System: Boc-Val-ψ-(CH2-NH)-Ala-Ala-pNA(223753-63-7)

Safety Data

• Hazardous Substances Data: 223753-63-7(Hazardous Substances Data)

Upstream product

• 50439-35-5 N^α-Boc-L-Ala-L-Ala-p-nitroanilide 
• 79069-51-5 (S)-N-tert-butoxycarbonylvalinal 
• 87694-52-8 tert-butyl (S)-1-(N-methoxy-N-methylcarbamoyl)-2-methylpropylcarbamate 
• 13734-41-3 t-Boc-L-valine 

Relevant articles and documents

Synthesis of some pseudo-peptide analogs of thiol proteinase inhibitors

Some pseudo-peptide analogs of thiol proteinase inhibitors were synthesized by a conventional solution method. Among them, Suc-Ala-Val-Val- Ala-Ψ-(CH2-NH)-Ala-pNA (peptide 1) and Suc-Ala-Val-Val-Ψ-(CH2NH)-Ala- Ala-pNA (peptide 2) showed a stronger inhibitory activity compared with parent peptide such as Suc-Ala-Val-Val-Ala-Ala-pNA. In particular, peptide 2 was about 10-fold as active as the parent peptide (IC50=8 μM). Inserting Ψ-(CH2-NH) possibly makes the inhibitor less susceptible to papain and, as a result, pro-duces more potent inhibition.