223763-44-8Relevant academic research and scientific papers
Heterocyclic synthesis containing bridgehead nitrogen atom: Synthesis of 3-[(2H)- 2-oxobenzo[b]pyran-3-yl]-s-triazolo[3,4-b]-1,3,4-thiadiazine and thiazole derivatives
Raslan
, p. 114 - 120 (2003)
The reaction of 2H-2-oxobenzo[b]-pyran-3-hydrazide (2) with carbon disulfide in basic DMF afforded potassium thiocarbamate 3, which readily underwent heterocyclization upon its reaction with hydrazine and/or phenacyl bromide to yield 1,2,4-tiazole (4) and thiazole 7 derivatives, respectively. Condensation of 4 with substituted phenacyl bromide and/or chloranil gave 1,2,4-triazole[3,4-b]thiadiazine (5a,b) and 3,10-bis-[2H-2-oxobenzo[b]pyran-3-yl]-6,13-dichloro-bis-[2H-2-oxobenzo[b]pyran-3 -yl]- 6,13-dichloro-bis-1,2,4-triazolo[3,4-b]-1,3,4-thiadiazino [5′,6′-b:5′,6′-e]cyclohexa-1,4-diene (6), respectively. Cyclization of thiosemicarbazide 10 by refluxing it in sodium hydroxide and/or phosphoryl chloride afforded triazole 13 and thiadiazole 15 derivatives, respectively. Also, 10 reacted with phenacyl bromide in the presence of anhydrous sodium acetate to give the oxothiazolidine derivative 17. The structure of the synthesized compounds were confirmed by elemental analyses, IR, 1H NMR, and mass spectra.
Uses of 1-cyanoacetyl-4-phenyl-3-thiosemicarbazide in heterocyclic synthesis: Synthesis of thiazole, coumarin, and pyridine derivatives with antimicrobial and antifungal activities
Mohareb, Rafat M.,Ho, Jonathan Z.,Mohamed, Abeer A.
, p. 1661 - 1681 (2008/02/11)
The reaction of cyanoacetyl hydrazine with phenylisothiocyanate gave the thiosemicarbazide 3. The latter underwent a series of heterocyclization reactions when it reacts with either aromatic aldehydes or -haloketones, follwed by further reaction of the pr
Anti-inflammatory benzopyran-2-ones and their active oxygen species (aos) scavenging activity
Bhalla,Shukla,Gujrati,Saxena,Sanger,Shanker
, p. 403 - 411 (2007/10/03)
Benzopyrano derivatives were synthesized and evaluated for their anti- inflammatory, ulcerogenic activities and toxicity studies. The in-vitro studies comprised of anti-proteolytic activity, lipid peroxidation inhibitory and reducing activities against α,α-diphenyl-β-picrylhydrazyl (DPPH). Two potent compounds were studied further for their inhibition of lipid peroxidation and effect on Superoxide dismutase (SOD) activity in-vivo. These compounds were found promising in all the parameters studied, thereby signifying inter-relationship between their anti-inflammatory activity and anti-oxidant properties.
