223768-08-9Relevant academic research and scientific papers
COMPOSITIONS AND METHODS FOR TREATING HYPERPROLIFERATIVE DISEASE
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Page/Page column 76, (2008/12/06)
The present disclosure provides amide-based, non-nucleoside compounds having an inhibitory activity against endogenous polymerases, such as polymerase alpha and polymerase gamma. This disclosure further provides uses of treating hyperproliferative disease
NON-NUCLEOSIDE ANTI-HEPACIVIRUS AGENTS AND USES THEREOF
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Page/Page column 77, (2010/11/25)
The present dislcosure provides amide-based, non-nucleoside compounds having antiviral activity against Hepacivirus, such as hepatitis C virus (HCV), methods and intermediates for synthesizing such compounds, and methods of using the compounds in a variety of contexts, including in the treatment and prevention of viral infections. The present dislcosure also provides methods for identifying amide-based, non-nucleoside compounds having antiviral activity.
Identification of inhibitors of an 80 kDa protease from Trypanosoma cruzi through the screening of a combinatorial peptide library
Vendeville, Sandrine,Buisine, Eric,Williard, Xavier,Schrevel, Joseph,Grellier, Philippe,Santana, Jaime,Sergheraert, Christian
, p. 194 - 198 (2007/10/03)
Two orthogonal peptide combinatorial libraries were screened to discover inhibitors of Tc80 protease, a novel target from Trypanosoma cruzi involved in host cell invasion. These libraries were composed of 15625 structurally diversified tripeptides, partit
