223786-65-0Relevant academic research and scientific papers
2-Arylamino-4-amino-5-aroylthiazoles. "One-pot" synthesis and biological evaluation of a new class of inhibitors of tubulin polymerization
Romagnoli, Romeo,Baraldi, Pier Giovanni,Carrion, Maria Dora,Cruz-Lopez, Olga,Cara, Carlota Lopez,Basso, Giuseppe,Viola, Giampietro,Khedr, Mohammed,Balzarini, Jan,Mahboobi, Siavosh,Sellmer, Andreas,Brancale, Andrea,Hamel, Ernest
supporting information; experimental part, p. 5551 - 5555 (2010/02/28)
The essential role of microtubules in mitosis makes them a major target of compounds useful for cancer therapy. In our search for potent antitumor agents, a novel series of 2-anilino-4-amino-5-aroylthiazoles was synthesized and evaluated for antiprolifera
THIAZOLE AND THIOPHENE ANALOGUES, AND THEIR USE IN TREATING AUTOIMMUNE DISEASES AND CANCERS
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Page/Page column 86, (2008/06/13)
Thiazole and thiophene compounds are disclosed having utility in treating inflammatory conditions, immunoinflammatory conditions, autoimmune diseases, and cancers. Methods for the synthesis of these compounds are also disclosed.
Inhibitors of glycogen synthase kinase-3 (gsk-3) for treating glaucoma
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, (2008/06/13)
The use of inhibitors of GSK-3 useful for treating glaucoma is disclosed.
Use of 2,4-diaminothiazole derivatives
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, (2008/06/13)
2,4-Diaminothiazole derivatives which inhibit GSK-3 (glycogen synthase kinase-3) and which are useful for the treatment and/or prevention disorders and diseases wherein an inhibition of GSK-3 is beneficial, especially especially Alzheimer's disease, bipolar disorder, IGT (impaired glucose tolerance), Type 1 diabetes, Type 2 diabetes and obesity.
A new general three component solution-phase synthesis of 2-amino-1,3-thiazole and 2,4-diamino-1,3-thiazole combinatorial libraries
Masquelin, Thierry,Obrecht, Daniel
, p. 153 - 156 (2007/10/03)
A general procedure for the solution-phase synthesis of amino-1,3-thiazole libraries 9 and 10 is described. Their preparation is based on the condensation of amidines 1 and thiouronium salts 2 with isothiocyanates 3, affording amidino-thioureas and thiour
