223797-21-5Relevant academic research and scientific papers
Exploration of the molecular architecture of the orthosteric binding site in the α4β2 nicotinic acetylcholine receptor with analogs of 3-(dimethylamino)butyl dimethylcarbamate (DMABC) and 1-(pyridin-3-yl)-1,4-diazepane
Bach, Tinna B.,Jensen, Anders A.,Petersen, Jette G.,S?rensen, Troels E.,Della Volpe, Serena,Liu, Jun,Blaazer, Antoni R.,Van Muijlwijk-Koezen, Jacqueline E.,Balle, Thomas,Fr?lund, Bente
, p. 425 - 444 (2015/09/01)
X-ray crystal structures of acetylcholine binding proteins (AChBPs) have revealed two different possible extensions to the classical ligand binding pocket known to accommodate various nicotinic agonists. One of the pockets is limited in size while the oth
Heteroaryl diazacycloalkanes, their preparation and use;
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Page/Page column 21, (2010/11/30)
The present invention discloses compounds of the formula any of its enantiomers or any mixture thereof, isotopes thereof or a pharmaceutically acceptable salt thereof; wherein n is 1, 2 or 3; m is 0, 1 or 2; R represents hydrogen, alkyl, cycloalkyl, cyclo
Novel potent ligands for the central nicotinic acetylcholine receptor: Synthesis, receptor binding, and 3D-QSAR analysis
Nielsen, Simon Feldb?k,Nielsen, Elsebet ?stergaard,Olsen, Gunnar M.,Liljefors, Tommy,Peters, Dan
, p. 2217 - 2226 (2007/10/03)
In the past few years the focus on central acetylcholine receptors has shifted from-compounds with affinity for muscarinic acetylcholine receptors (mAChR) to compounds with affinity for nicotinic acetylcholine receptors (nAChR). The therapeutic potential
