22385-36-0

Basic information

• Product Name: 2-HYDROXY-6-METHOXYPYRIDINE
• Synonyms: 2-HYDROXY-6-METHOXYPYRIDINE;2(1H)-Pyridinone,6-methoxy-(9CI);6-Methoxy-2(1H)-Pyridinone;6-Methoxypyridin-2(1H)-one;6-Methoxy-2-pyridone;6-methoxypyridin-2-ol
• CAS NO: 22385-36-0
• Molecular Formula: C₆H₇NO₂
• Molecular Weight: 125.13
• Product Categories: PYRIDINE
• Mol File: 22385-36-0.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 354.2°Cat760mmHg
• Flash Point: 168°C
• Appearance: /
• Density: 1.16g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.527
• CAS DataBase Reference: 2-HYDROXY-6-METHOXYPYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-HYDROXY-6-METHOXYPYRIDINE(22385-36-0)
• EPA Substance Registry System: 2-HYDROXY-6-METHOXYPYRIDINE(22385-36-0)

Safety Data

• Hazardous Substances Data: 22385-36-0(Hazardous Substances Data)

Usage

General Description

2-Hydroxy-6-methoxypyridine is a chemical compound with the molecular formula C6H7NO2. It is a derivative of pyridine and contains a hydroxyl group and a methoxy group on the aromatic ring. This chemical is often used in the synthesis of pharmaceuticals and agrochemicals due to its unique structure and reactivity. It may also be used as a building block in organic synthesis for the production of various compounds. Additionally, 2-Hydroxy-6-methoxypyridine has been found to exhibit antioxidant and anti-inflammatory properties, making it a potentially valuable ingredient in the development of therapeutic agents. Overall, this chemical compound has a wide range of potential applications in the fields of medicine, agriculture, and chemical research.

InChI:InChI=1/C6H7NO2/c1-9-6-4-2-3-5(8)7-6/h2-4H,1H3,(H,7,8)

Upstream product

• 75608-94-5 5-methoxy-3-oxo-2-azabicyclo<2.2.0>hex-5-one 

Downstream Products

• 108279-81-8 7b-methoxy-5-oxo-1a,2,3,5,7a,7b-hexahydro-1H-cyclobutaindolizine 
• 1446007-93-7 (S)-N-(1-{4-[3-(6-methoxy-pyridin-2-yloxy)-azetidin-1-yl]-phenyl}-ethyl)-acetamide 

Relevant articles and documents

Equilibrium and Activation Thermodynamic Parameters of the Tautomerism of 6-Methoxy-2-pyridone in Water

In neutral water, the interconversion of the two tautomers of the lactim-lactam equilibrium of 6-methoxy-2-pyridone occurs essentially via a pH-independent process.The influence of temperature on the position and on the dynamics of this tautomeric equilibrium has been studied by temperature-jump relaxation kinetics.The equilibrium and activation thermodynamic parameters obtained (ΔH0 26.8 kJ mol-1, ΔS0 58 J K-1 mol-1; lactam -> lactim, ΔHC(excit.) 46 kJ mol-1, ΔSC(excit.) -40 J K-1 mol-1) indicate a high value for the kinetic entropy term.These results indicate that the interconversion mechanism is ionic (rather than concerted) and involves the anionic form of the substrate in a cyclic transition state.In this transition state, at least two solvent molecules would temporarily ensure a hydrogen bond connection between the sites which undergo tautomerism.

Syntheses and Ring-opening Reactions of 5-Alkoxy- and 5-Acetoxy-3-oxo-2-azabicyclohex-5-enes

The efficient photochemical synthesis of 5-alkoxy- and 5-acetoxy-3-oxo-2-azabicyclohex-5-enes (2a-e and f, g), and a new rearrangement reaction of the former compounds (2a-e) to 6-alkoxy-2-pyridones (3a-e), are reported.